Racecadotril-Acetorphan-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERacecadotrilCat. No.: HY-17399CAS No.: 81110-73-8Synonyms: Acetorphan分式: CHNOS分量: 385.48作靶點: Neprilysin作通路: Metabolic Enzyme/Protease儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 100 mg/m

2、L (259.42 mM)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.49 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (6.49 mM); Suspended solution; Need ultrasonic3. 請依序添加每種溶劑： 10% DMSO 90% corn oil

3、Solubility: 2.5 mg/mL (6.49 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Racecadotril (acetorphan)是腦啡肽酶抑制劑，IC50為4.5 uM，能抑制內(nèi)源的腦啡肽降解。REFERENCES1. Marion Eberlin, Tobias Mck, Martin C. Michel, et al. A Comprehensive Review of the Pharmacodynamics, Pharmacokinetics, andClinical Effects of the Neutral Endop

4、eptidase Inhibitor Racecadotril. Front Pharmacol. 2012; 3: 93.2. Wu HT, Chang CK, Cheng KC, et al. Increase of plasma insulin by racecadotril, an inhibitor of enkephalinase, in Wistar rats. HormMetab Res. 2010 Apr;42(4):261-7.3. Szajewska H, Ruszczyski M, Chmielewska A, Wieczorek J. Systematic revie

5、w: racecadotril in the treatment of acute diarrhoea inchildren. Aliment Pharmacol Ther. 2007 Sep 15;26(6):807-13.4. Schwartz JC. Racecadotril: a new approach to the treatment of diarrhoea. Int J Antimicrob Agents. 2000 Feb;14(1):75-9.5. RacecadotrilMcePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-5