生物資訊內(nèi)涵

1、From Sequence to StructureSources on Web生物資訊內(nèi)涵Gene , Protein 序列, 結(jié)構(gòu), 功能比對(duì), 預(yù)測(cè), 分類 , 關(guān)聯(lián), 註解基因碼Genetic CodeIn form of codon, Left-Top-Right TCAGTPheSerTyrCysTCLeuTerTerATrpG CLeuProHisArgTCGlnAGAIleThrAsnSerTCLysArgAMetGGValAlaAspGlyTCGluAGhttp:/www.cmbi.kun.nl/swift/future/aainfo/gencode.htmlCodon Th

2、ree bases in a DNA or RNA sequence which specify a single amino acid.生物資訊網(wǎng)路資源Sequence Retrieve System.tw/wong/courses/inform/site05.htmhttp:/www.ebi.ac.uk/歐洲生物資訊研究所 The European Bioimformatics Institute 生物資訊網(wǎng)路資源資料庫(kù)分類主要序列儲(chǔ)存基因體資料庫(kù)蛋白質(zhì)資料庫(kù)結(jié)構(gòu)資料庫(kù)分子間作用資料庫(kù)突變資料庫(kù)文獻(xiàn)資料庫(kù)生物資訊網(wǎng)路資源基因資料庫(kù)GDBgenome database /GenbankNIH

3、 genetic sequence /Genbank/Genomenet http:/www.genome.jp/DNA 資料庫(kù)EMBLnucleic acid database http:/www.ebi.ac.uk/embl/index.htmlNDBnucleic acid database /NDB/RNA 資料庫(kù)RDP rRNA sequences /html/生物資訊網(wǎng)路資源蛋白質(zhì)資料庫(kù)PIR protein Information resources Swiss-Prot/TrEMBL curated protein sequence http:/www.expasy.ch/sp

4、rot/PDB protein data bank /pdb/CATH protein structure classificationhttp:/www.biochem.ucl.ac.uk/bsm/cath_new/ SCOP protein Structural classificationhttp:/scop.mrc-lmb.cam.ac.uk/scop/生物資訊網(wǎng)路資源教學(xué)資源NEE-HOW, POST, 莊榮輝教授教學(xué)網(wǎng)業(yè)(臺(tái)大農(nóng)化)核酸DNA from the beginning - Cold Spring Harbor Laboratory, New York (USA)Stru

5、cture of DNA - /molvis/freichsman/NucAcids/Helix/hmenu.html胺基酸Amino acid properties - University of California. Davis (USA)Amino acid information - European Molecular Biology Lab-Heidelberg (German)蛇毒傳奇-清華大學(xué) (Taiwan)蛋白質(zhì)Principles of Protein Structure Using the Iternet - Birkbeck College-London (UK)生

6、物資訊Using Internet Resources in Molecular Biology-San Diego Supercomputer center(USA)生命科學(xué)線上教學(xué) - 清華大學(xué)生物資訊中心 (Taiwan)BioInfoFab - 陽(yáng)明大學(xué)生物資訊中心 (Taiwan)生物資訊網(wǎng)路資源參考查詢資源HINT - 國(guó)家衛(wèi)生研究院醫(yī)藥衛(wèi)生研究資訊網(wǎng) (Taiwan) .tw/Entrez(PubMed) National Center of biotechnology Information (USA) /entrez/query.fcgi?db=PubMedhttp:/ave

7、rmitilis.ls.kitasato-u.ac.jp/Streptomyces avermitilis is an industrial microorganism produced anthelmintic macrolide Avermectins. 序列分析與結(jié)構(gòu)預(yù)測(cè)核酸 蛋白質(zhì)核酸序列蛋白質(zhì)序列蛋白質(zhì)性質(zhì)蛋白質(zhì)結(jié)構(gòu)資料庫(kù):GenBank工具:Blast基因比對(duì)網(wǎng)站: Expasy工具:MBS translator基因轉(zhuǎn)譯核酸序列蛋白質(zhì)序列蛋白質(zhì)特性pI 質(zhì)與分子量網(wǎng)站: Expasy工具:PI/MW computeMGKIGIFFGTDSGNAEAIAEKISKAIGNAEVIDV

8、AKASKDQFNSFTKVILVAPTAGAGDLQTDWEDFLGTLEASDFANKTIGLVGLGDQDTYSETFAEGIFHIYEKAKAGKVVGQTPTDGYHFEASKAVEGGKFVGLVIDEDNQDDLTDGRISKWVEQIKGSFAAGILPVFYWDENQRHSTKCMMGKIGIFFGTDSGNAEAIAEKISKAIGNAEVIDVAKASKDQFNSFTKVILVAPTAGAGDLQTDWEDFLGTLEASDFANKTIGLVGLGDQDTYSETFAEGIFHIYEKAKAGKVVGQTPTDGYHFEASKAVEGGKFVGLVIDEDNQDDLTDG

9、RISKWVEQIKGSFA HydrophobicALIVMWMGKIGIFFGTDSGNAEAIAEKISKAIGNAEVIDVAKASKDQFNSFTKVILVAPTAGAGDLQTDWEDFLGTLEASDFANKTIGLVGLGDQDTYSETFAEGIFHIYEKAKAGKVVGQTPTDGYHFEASKAVEGGKFVGLVIDEDNQDDLTDGRISKWVEQIKGSFA PositiveKHRMGKIGIFFGTDSGNAEAIAEKISKAIGNAEVIDVAKASKDQFNSFTKVILVAPTAGAGDLQTDWEDFLGTLEASDFANKTIGLVGLGDQDTY

10、SETFAEGIFHIYEKAKAGKVVGQTPTDGYHFEASKAVEGGKFVGLVIDEDNQDDLTDGRISKWVEQIKGSFA AromaticFWY一級(jí)結(jié)構(gòu)分析胺基酸標(biāo)示網(wǎng)站: Expasy工具: Colorseq三級(jí)結(jié)構(gòu)預(yù)測(cè)網(wǎng)站: Expasy工具: 3D-PSSMTHE PAIRWISE RMSD BETWEEN THE STRUCTURES IS : 0.131181 1 : /pdb1czlA_0.tmp TEMPLATE 2 : /model_1.pdb SELECTED待測(cè)蛋白質(zhì)序列資料庫(kù)蒐尋蛋白質(zhì)序列比對(duì)是否有PDB資料yes比對(duì)模擬預(yù)測(cè)二級(jí)結(jié)構(gòu)No折疊辨認(rèn)是否有折疊資料二級(jí)結(jié)構(gòu)比對(duì)序列-結(jié)構(gòu)比對(duì)預(yù)測(cè)三級(jí)結(jié)構(gòu)Noyes3D 結(jié)構(gòu)模型http:/www.bmm.icnet.uk/people/rob/CCP11BBS/flowchart2.html序列結(jié)構(gòu)蛋