糖尿病的細(xì)胞替代治療

DM：

cellreplacementtherapystemcellDM2CONTENTS1.replacementtherapyforDM2.pancreaticstemcell3.EPC4.CB-SC11.celltherapyforT1DMautoimmuneattack

againstinsulin-producingcells(Gepts,1965)Type1diabetes(T1D)24bigeventsCELLTHERAPYPaulE.Lacy1972mice1989humanCamillo

Ricordi/wiki/%E8%83%B0%E5%B2%9B%E7%A7%BB%E6%A4%8DJamesShapiroEdmonton方案（西羅莫司，他克莫司，達(dá)克珠單抗）thesourceofβ-cellsideapurifier32.pancreaticstemcell胰島分離后，胰腺仍保持相應(yīng)消化功能在體外研究中，收集新胰島細(xì)胞能發(fā)現(xiàn)其從胰導(dǎo)管上皮生芽的現(xiàn)象?？赡艽嬖谝葝u細(xì)胞來源不清的問題SusanBonner-Weir,Wan-ChunLi,etal.Diabetes.Oct

2010;59(10):2340-23484ShigeruYatoh,RikkeDodge,etal.DiabetesJuly2007vol.56no.71802-18095startingcellexpandedcellsaggregatesgraftCK19+(green)insulin+(red)7胰島素陽性細(xì)胞來源于胰管細(xì)胞移植物中胰島素陽性細(xì)胞生長不規(guī)律,功能不夠完善成瘤性CellStemCell10,371–384,April6,2012a2012

ElsevierInc.3.endodermalprogenitor

(EP)cellday12day188由EP細(xì)胞能分化出成熟的β細(xì)胞該細(xì)胞團(tuán)中只有分泌胰島素的細(xì)胞

EPCellsLackTumorigenicityandFormEndodermal

TissuesInVivoESCEPC94.CB-SC

-cordblood-derivedmultipotentstemcells20000多例CBT，100多個(gè)臍血庫中儲(chǔ)藏了400000臍血單位。（BoneMarrowDonorsWorldwide(BMDW),January2009）提示資源豐富

YongZhao?,Theodore10NGFnegtivecontrolFicoll-Hypaque11exendin-4+葡萄糖治療自身免疫性糖尿病新理念toppriority：controlofautoimmunitysubordinate:reconstructionoffunctionalislets

purifiedCD4+CD62L+Tregs(mCD4CD62LTregs)

treatmentofspontaneously-developedautoimmune-

causeddiabetesinNODmicecontrolgroup：1.purifiedCD4+CD62L+Tregsfromlymphocytesnotco-culturedwith CB-SC 2.InjectionofvehiclePBSZhaoY,LinB,DarflingerRet,al.PLoSONE2009;4:e4226.12成瘤性的減弱H13機(jī)制：mCD4CD26LTreg細(xì)胞糾正