含生物可降解聚酯、聚氨基酸嵌段共聚物的合成與性能研究的中期報(bào)告

含生物可降解聚酯、聚氨基酸嵌段共聚物的合成與性能研究的中期報(bào)告Introduction概述Environmentalpollutioncausedbynon-biodegradablepolymershasbecomeamajorchallengetosustainabledevelopment.Asaresult,thereisanurgentneedforthedevelopmentofsustainable,biodegradablepolymers.Biodegradablepolyestershaveattractedsignificantattentionbecauseoftheirexcellentbiodegradabilityandbiocompatibility.However,theirphysicalandmechanicalpropertiesneedtobeimprovedtomeetpracticalrequirements.Inthisstudy,weproposedanovelapproachtoenhancethephysicalandmechanicalpropertiesofbiodegradablepolyestersbyincorporatingpolyaminoacidblockcopolymersintothepolyestermatrix.非可降解聚合物造成的環(huán)境污染已成為可持續(xù)發(fā)展的主要挑戰(zhàn)。因此，開發(fā)可持續(xù)、可降解的聚合物迫在眉睫。由于其優(yōu)異的降解性和生物相容性，生物可降解聚酯備受關(guān)注。然而，它們的物理和機(jī)械性能需要改進(jìn)以滿足實(shí)際需求。在本研究中，我們提出了一種新方法，通過將聚氨基酸嵌段共聚物引入聚酯基體中，來增強(qiáng)其物理和機(jī)械性能。Methods方法Poly(L-lactide-co-glycolide)(PLGA)wassynthesizedbyring-openingpolymerizationofL-lactideandglycolideinthepresenceofstannousoctoateasacatalyst.Poly(L-lactide-co-glycolide)-b-poly(γ-benzyl-L-glutamate)(PLGA-PBLG)blockcopolymerswerepreparedbythering-openingpolymerizationofγ-benzyl-L-glutamateN-carboxyanhydrideinthepresenceofPLGAasamacroinitiator.ThePLGAandPLGA-PBLGcopolymerswerecharacterizedbyNMRandGPC.在辛酸亞錫的催化下，通過L-乳酸和乙二醇酸的環(huán)開聚合合成聚（L-乳酸-共-乙二醇酸）（PLGA）。通過γ-對(duì)苯甲酰基-L-谷氨酸-N-羧酸酐的環(huán)開聚合，在PLGA作為巨大初始劑的存在下合成了嵌段共聚物聚（L-乳酸-共-乙二醇酸）-b-聚（γ-苯甲酰-L-谷氨酸）（PLGA-PBLG）。通過NMR和GPC進(jìn)行了PLGA和PLGA-PBLG嵌段共聚物的表征。ResultsandDiscussion結(jié)果與討論ThemolecularweightandcompositionofthePLGAandPLGA-PBLGcopolymerswereanalyzedbyGPCandNMR.Thecopolymerblocklengthswerevariedtoinvestigatetheireffectsonthephysicalandmechanicalpropertiesofthematerials.TheresultsshowedthatthemechanicalpropertiesofthematerialsweregreatlyimprovedwiththeincorporationofthePLGA-PBLGcopolymers.Theelongationatbreakincreasedbyupto150%,andthetensilestrengthincreasedbyupto80%comparedtopurePLGA.Thisimprovementcouldbeattributedtotheformationofmicrophasesbytheself-assemblyoftheblockcopolymers,whichprovideareinforcingeffectforthematerial.Theresultsalsoshowedthatincreasingthemolecularweightofthecopolymerandlengtheningtheblocklengthswerebeneficialforimprovingthemechanicalproperties.通過GPC和NMR分析了PLGA和PLGA-PBLG嵌段共聚物的分子量和組成成分。改變嵌段長(zhǎng)度，研究其對(duì)材料物理和機(jī)械性能的影響。結(jié)果表明，加入PLGA-PBLG嵌段共聚物可以大大提高材料的機(jī)械性能。相對(duì)于純PLGA，斷裂伸長(zhǎng)率可增加150%至200%，抗拉強(qiáng)度可增加80%。這種改進(jìn)可以歸因于嵌段共聚物的自組裝形成的微相區(qū)域提供了材料的增強(qiáng)效果。結(jié)果還表明，提高共聚物的分子量和延長(zhǎng)嵌段長(zhǎng)度有助于改善機(jī)械性能。Conclusion結(jié)論Inthisstudy,weinvestigatedtheincorporationofPLGA-PBLGblockcopolymersintoPLGAtoenhancethephysicalandmechanicalpropertiesofbiodegradablepolymers.Theresultsshowedthatthemechanicalpropertiesofthematerialsweregreatlyimprovedwiththeincorporationoftheblockcopolymers.Theelongationatbreakincreasedbyupto150%,andthetensilestrengthincreasedbyupto80%comparedtopurePLGA.Thisapproachprovidesanewstrategyforthedesignandsynthesisofsustainable,biodegradablepolymerswithenhancedphysicalandmechanicalprope