甘露醇可用于治療帕金森癥

1、眼洛豊國(guó)皈萸勇irocky wltrmanofaal tmllmmmanni tol （甘露醇）,a sugar alcohol produced by fungi, bacteria, and algae, is a comm on comp on ent of sugar-free gum and candy. the sweete ner is also used in the medical field - it's approved by the fda as a diuretic （利尿劑）to flush out excess fluids and used during

2、 surgery as a substance that opens the blood/brain barrier to ease the passage of other drugs now profs. ehud gazit and daniel segal of tel aviv university*s department of molecular microbiology and biotech no logy and the sagol school of neuroscie nee, along with their colleague dr. ron it shalt ie

3、l-karyo and phd candidate mora n frenkel-pinter, have found that mannitol also prevents clumps of the protein osynuelein from forming in the brain - a process that is characteristic of parkinsorts diseasethese results, published in the journal of biological chemistry and presented at the drosophila

4、conference in washington, dc in april, suggest that this artificial sweetener could be a novel therapy for the treatment of parkinsorts and other neurodegenerative diseases the research was funded by a grant from the parkinson's disease foundation and supported in part by the lord allianee famil

5、y trustseeing a significant differenceafter identifying the structural characteristics that facilitate the development of clumps of a-synuclein, the researchers began to hunt for a compound that could inhibit the proteins' ability to bind together .in the lab, they found that mann itol was among

6、 the most effective agents in preventi ng aggregation of the protein in test tubes the ben efit of this substance is that it is already approved for use in a variety of clinical interventions, prof. segal says.next, to test the capabilities of marmitol in the living brain, the researchers turned to

7、transgenic fruit flies engineered to carry the human gene for a-synuclein. to study fly movement, they used a test called the ”climbing assay/1 in which the ability of flies to climb the walls of a test tube indicates their locomotive capability. in the initial experimental period, 72 percent of nor

8、mal flies were able to climb up the test tube, compared to only 38 percent of the genetically-altered flies.the researchers then added mannitol to the food of the genetically-altered flies for a period of 27 days and repeated the experiment this time, 70 percent of the mutated flies could climb up t

9、he test tube .in additi on, the researchers observed a 70 percent reduction in aggregates of a-synuelein in mutated flies that had been fed mannitol, compared to those that had not.these fin dings were con firmed by a sec ond study which measured the impact of mann itol on mice engineered to produce

10、 human cnsynuclein, developed by dr. eliezer masliah of the un iversity of san diego after four mon ths, the researchers found that the mice in jected with mannitol also showed a dramatic reduction of crsynuclein in the brain.delivering therapeutic compounds to the brainthe researchers now plan to r

11、e-examine the structure of the mannitol compound and introduce modifications to optimize its effectiveness. further experiments on animal models, including behavioral testing, whose disease development mimics more closely the development of parkinson's in humans is needed, prof. segal says.for t

12、he time being, mann itol may be used in combi nation with other medicati ons that have been developed to treat parki nson's but which have prove n in effective in breaking through the blood/brain barrier, says prof. segal. these medications may be able to "piggy-back" on mannitol's

13、 ability to open this barrier into the brain.although the results look prom ising, it is still not advisable for parkinson's patients to begin ingesting mannitol in large quantities, prof. segal cautions. more testing must be done to determine dosages that would be both effective and safe甘露糖醇（甘露

14、醇）的糖醇生產(chǎn)的其菌，細(xì)菌，藻類(lèi)，是無(wú)糖口否糖和糖果的共同紐.成部分。的甜味劑, 也可用于在醫(yī)療領(lǐng)域的-它被fda批準(zhǔn)作為利尿劑（利尿劑）扌if岀多余的流體，并在手術(shù)過(guò)程中使用的 物質(zhì)，打開(kāi)緩解其他藥物通過(guò)血/腦屏障?，F(xiàn)在兩位教授。待拉維夫大學(xué)分子微生物學(xué)與生物技術(shù)系和 sagol神經(jīng)科學(xué)學(xué)院，以及他們的同ron it shaltiel卡尤博士生莫蘭法蘭克品特，埃胡徳加齊特和丹尼爾西格爾發(fā)現(xiàn)，還可以防止的蛋白質(zhì)團(tuán)塊在大腦中形成的q共核蛋白一個(gè)過(guò)程，是帕 金森氏病的特征。這些研究結(jié)果發(fā)表在生物化學(xué)雜志，發(fā)表于4丿j在華盛頓特區(qū),在果蠅的會(huì)議，建議,這種人工甜味劑 可能是川于治療帕金森氏癥和具他神

15、經(jīng)退行性疾病的一種新型療法。資助這項(xiàng)研究是由帕金森氏癥叢金 會(huì)的資助和支持部分由主聯(lián)盟的家族信托?？吹揭粋€(gè)顯著差異識(shí)別的結(jié)構(gòu)特點(diǎn)，促進(jìn)發(fā)展的q-突觸核蛋口的團(tuán)塊后，研究人員開(kāi)始尋找一種化合物，能夠抑制蛋口質(zhì) 的能力結(jié)合在一起。在實(shí)驗(yàn)室屮，他們發(fā)現(xiàn)，甘露糖醇的最冇效的防止試管中的蛋口質(zhì)聚集劑。這種物 質(zhì)的好處是，它已被批準(zhǔn)用于在各種臨床干預(yù)，西格爾教授說(shuō)。接下來(lái)，為了測(cè)試的卄露醇在客廳大腦的能力，研究人員轉(zhuǎn)向蒼蠅工程進(jìn)行人類(lèi)基因a-synuclein的轉(zhuǎn) 基因水果。要研究飛運(yùn)動(dòng)，他們使川了所謂的“捋山測(cè)定測(cè)試”，在這種能力的蒼蠅爬壁試管中表示機(jī)車(chē) 能力。在最初的實(shí)驗(yàn)期間，72%的正常果蠅能夠爬上試管，而只冇38%的基因改變的蒼蠅。然后，研究人員添加甘露醇食品的基因改變了一個(gè)為期27夭的蒼蠅，反復(fù)的實(shí)驗(yàn)。這一次，70%的變 異蒼蠅爬上試管。此外，研究人員觀察到減少70%的6突觸核蛋白的聚集變異蒼蠅-立喂ft露醇相比, 那些有。這些發(fā)現(xiàn)證實(shí)了第二項(xiàng)研究測(cè)量的影響甘需醇對(duì)小鼠設(shè)計(jì)生產(chǎn)人q-突觸核蛋白開(kāi)發(fā)的的埃利澤masliah 博士圣地亞哥人學(xué)。4個(gè)片后，研究人員發(fā)現(xiàn)，小鼠注射h露醇a突觸核蛋白在大腦中也出現(xiàn)了大幅度的減少。治療化合物交付到大腦研究人員現(xiàn)在打算重新審視卄露醇化合物的結(jié)構(gòu)和引入的修改，優(yōu)化其有效性。進(jìn)一步的實(shí)驗(yàn)動(dòng)物