奧硝唑注射液與常用注射液的配伍穩(wěn)定性研究

1、【摘要】目的 研究奧硝唑注射液與常用注射液的配伍穩(wěn)定性。方法 對奧硝唑注射液與常用14種注射液配伍穩(wěn)定性進(jìn)行總結(jié)性分析。結(jié)果 奧硝唑可與11種藥物配伍使用,穩(wěn)定性較好。與炎琥寧、阿魏酸鈉和奧美拉唑配伍后出現(xiàn)沉淀,提示藥物之間有配伍禁忌。結(jié)論 奧硝唑與其他注射液配伍應(yīng)用時應(yīng)謹(jǐn)慎,保證配伍穩(wěn)定性及安全用藥?！娟P(guān)鍵詞】奧硝唑注射液;配伍;穩(wěn)定性【中圖分類號】R942 【文獻(xiàn)標(biāo)識碼】B 【文章編號】1674-9316(201509-0214-02Analysis on Stability of Compatibility Between Ornidazole Injection and Common

2、in JectionZHANG Xiaohua Peoples Hospital of Fuyu County in Heilongjiang Province,Qiqihar 161200,China【Abstract】Objective Stability of compatibility between ornidazole injection and common injection is to be analyzed. Methods Make a summative analysis on stability of compatibility between ornidazole

3、injection and other 14 kinds of common injection. Results Ornidazole injection is of stability to be compatible with 11 kinds of common injection; however, there is precipitation to be seen after combination between ornidazole injection with Yanhuning, sodium ferulate or omeprazole, which is taken a

4、s a sign of medication incompatibility. Conclusion It is required to be careful to get ornidazole injection combined with other kinds of infections, which is of importance to guarantee compatibility stability and medication safety.【Key words】Ornidazole injection,Compatibility,Stability奧硝唑注射液為臨床常用藥。目

5、前,隨著藥理作用研究的不斷深入及成熟,該藥物應(yīng)用逐漸廣泛,且應(yīng)用時多與其他液體配伍,交替輸入患者體內(nèi)。奧硝唑與其他藥物混合后有無配伍問題是藥理研究的主要方向?，F(xiàn)對奧硝唑注射液與常用14種注射液配伍穩(wěn)定性進(jìn)行總結(jié)性分析,并將分析結(jié)果報(bào)告如下。1 奧硝唑注射液與常用14種注射液配伍分析1.1 頭孢菌素類1.2 其他藥物2 結(jié)果分析顯示,奧硝唑可與頭孢呋辛鈉、頭孢噻肟鈉、頭孢拉定、頭孢哌酮鈉、頭孢匹胺鈉、頭孢吡肟、頭孢曲松鈉、頭孢替唑鈉、維生素C、阿奇霉素、左氧氟沙星11種藥物配伍使用,穩(wěn)定性較好。與炎琥寧、阿魏酸鈉和奧美拉唑配伍后出現(xiàn)沉淀,提示藥物之間有配伍禁忌。3 討論奧硝唑適用于臨床治療由多形

6、擬桿菌、脆弱擬桿菌、真桿菌、幽門螺桿菌、梭桿菌、消化鏈球菌等敏感厭氧菌導(dǎo)致的感染性疾病,具體包括外科感染、口腔感染、腹部感染、盆腔感染、腦部感染等1。工作單位:161200黑龍江省富裕縣中醫(yī)院 工作單位:152100黑龍江省望奎縣中醫(yī)院ZHAO Haixia Hospital of Traditional Chinese Medicine of Wangkui County in Heilongjiang Province,Suihua 152100,China 【Abstract】Objective The application effect of Azithromycin treatme

7、nt in children patients with pneumonia is to be researched. Methods Choose 59 children patients with pneumonia who are treated in clinic department from May 2013 to May 2014 and separate them into study group (Erythromycin and control group (Azithromycin according to different treatment methods, and

8、 then observe and compare the treatment efficiency of the two groups. Results Compared to control group, the treatment efficiency in study group is much higher and the symptoms of patients in study group have been alleviated faster, and the side-effects in study group are less. There is a great trea

9、tment differential between two groups and such a differential has statistic value(P <0.05. Conclusion Azithromycin treatment is rather effective to cure children patients with pneumonia; it is conducive to relieving illness symptoms and curing patients quickly with less side effects, which is sug

10、gested to be promoted and applied.【Key words】Children patients with Pneumonia,Azithromycin,Treatment阿奇霉素在小兒肺炎治療中的應(yīng)用研究趙海霞小兒肺炎是臨床兒科常見呼吸道疾病。該病并發(fā)癥較多,若能得到有效及時治療,則可避免并發(fā)癥;重癥患兒易并發(fā)膿氣胸、心力衰竭、中毒性休克、缺氧性腦病、呼吸衰竭、中毒性腸麻痹和中毒性休克等,還可并發(fā)肺氣腫、支氣管擴(kuò)張癥、肺不張和肺大泡等。為了減少并發(fā)癥,緩解癥狀,殺滅病原菌,應(yīng)積極給予患者治療?，F(xiàn)搜集2013年5月2014年5月我院接收的小兒肺炎59例患兒,對其阿奇

11、霉素在治療中的應(yīng)用效果進(jìn)行總結(jié)性分析,并將分析結(jié)果報(bào)告如下。1 資料和方法1.1 一般資料搜集2013年5月2014年5月我院接收的小兒肺炎59例患兒,按照治療方法不同分為對照組、研究組。對照組共29例,平均年齡是(5.25±1.02歲,年齡范圍是6個月11歲,男患兒和女患兒分別是16例、13例。研究組共30例,平均年齡是(5.32±1.03歲,年齡范圍是6個月11.3歲,男患兒和女患兒分別是17例、13例。對照組與研究組的一般臨床資料相比,無明顯差異,無統(tǒng)計(jì)學(xué)意義(P >0.05。1.2 方法充分混合后,給予患兒靜滴,共7 d 。7 d 后,使用紅霉素片,每日3次,每次30 mg/(kg ·d ,給予患兒口服,共7 d 。觀察對照組與研究組的臨床療效及不良反應(yīng),并比較。準(zhǔn)確記錄兩組癥狀消失時間,并對比。1.3 療效標(biāo)準(zhǔn)無效:患兒經(jīng)藥物治療后,肺部啰音、咳嗽、高熱、咽痛、厭食和畏寒等癥狀較治療前