含馬齒莧及大豆精華提取物護膚品的美白功效觀察-精選文檔

1、含馬齒莧及大豆精華提取物護膚品的美白功效觀察Whitening effect of purslane and soy extractsJIANG Li-li,LI Yuan-hong,WU Yan,XIAO Ting,GAO Xing-hua,CHEN Hong-duoDepartment of Dermatology, the First Hospital of China Medical University, Key Laboratory of Immunodermatology, Ministry of Health (China Medical University) Shenyan

2、g 110001,Liaoning, China: ObjectiveTo evaluate the whitening effect of purslane and soy extracts.MethodsForty photoaging subjects were randomly divided into the control group and the treatment group. The combination of the three whitening products, including day cream, night cream and ampoule, which

3、 contain different ratios of purslane and soy extracts.Day cream and night cream were topically applied to all subjects. Ampoule cream was additionally applied to the subjects of the treatment group. The study was conducted for 12 weeks. Noninvasive instruments were used to measure the L*a*b* value,

4、 melanin index (MI) and erythema index (EI). Subjective assessments were conducted by ablinded dermatologist and subjects concerning of theimprovement of skin color.ResultsOn week 4 and 12, the L* value of the treatment group significantly increased, and the b* and MI values of this group significan

5、tly decreased. Meanwhile the charge of MI value of the control group was not obviously decreased until on week 12. The a* and EI values of both groups dont changed much. On week 4, 35% subjects in the control group improved slightly, meanwhile 63% subjects in the treatment group improved slightly to

6、 moderately. On week 12, 40% subjects in the control group obtained slightto moderate improvements. 79% subjects inthe control treatment group obtained slight to moderate improvements. No erythema, telangiectasis, or edema was observed in both groups. Conclusion The combination of the three whitenin

7、g products could effectively whiten the skin.東方女性歷來追求柔嫩、白皙的肌膚 , 因而各種美白護膚品 受到眾多愛美女士的青睞 , 尤其含有植物提取物的產(chǎn)品。最近 , 強生公司研發(fā)了一系列新型美白護膚產(chǎn)品 , 其主要的有效成分包 括馬齒莧及大豆精華提取物。 本研究采用隨機對照方法觀察了該 護膚產(chǎn)品的美白療效 , 現(xiàn)報道如下。1 對象和方法1.1研究對象:納入標準:3060歲面部光老化女性受試 者; 自愿參加本研究并簽署知情同意書。 排除標準 : 對本產(chǎn)品 中任何成分有過敏史者 ; 妊娠或哺乳期婦女 ; 近期使用過 ( 內(nèi) 服或外用 ) 類固醇類藥物或

8、抗組胺類藥物者 ; 有系統(tǒng)性疾病或 皮膚病者 ; 不能按要求使用本產(chǎn)品者 ; 不能按時隨訪者。1.2 研究方法1.2.1 護膚品來源及種類 :由強生中國 (露得清 )提供,主要 成分包括馬齒莧、大豆精華提取物及維生素(A、B、C), 根據(jù)配比比例不同制成日霜 ( 含防曬劑 SPF20/PA+) 、晚霜、精華素。1.2.2 受試者分組方法 : 按隨機數(shù)字表將所有受試者隨機分 為對照組及試驗組 , 兩組受試者均于每日晨起潔面后外用日霜、 睡前潔面后外用晚霜 , 試驗組于應用上述護膚品前外用精華素。 整個研究持續(xù) 12 周。123照片留取:于治療前(W0)、2周后(W2)、4周后(W4)、 12周后

9、(W12)分別用數(shù)碼相機(Coolpix 5700,Nikon, 日本)留取 受試者正位及雙側(cè)位 45的照片。1.2.4 非創(chuàng)傷性檢測 : 于上述 4個時間點進行檢測。應用分 光測色儀 (Spectrophometry CM2600D,Minolta, 日本)對受試者 眉正中上方1cm眼外眥旁1cm顴骨最高部位及唇旁1cm共4 個部位進行 L*a*b* 值測定,每個部位測 3次,取平均值;應用窄譜 反射分光光度計 (Mexameter MX18,Courage+Khazaka electronic GmbH,Colog ne,德國)對上述四個部位進行黑素指數(shù) (mela nin index,M

10、I) 和紅斑指數(shù) (erythema index,EI) 測定 , 每個部位測 3次 , 取平均值。125 主觀評價:于 W2 W4 W12由一位未參加本試驗的皮膚科醫(yī)生根據(jù)照片及受試者本人對皮膚色澤的 改善程度進行評價 , 分為無改善、輕度改善、中度改善及明顯改 善四個等級。126 數(shù)據(jù)處理及分析:采用SPSS 16.0 FOR WINDOW進行 數(shù)據(jù)處理。 計量資料采用 t 檢驗、等級資料采用非參數(shù)檢驗進行 分析,P0.05）。2.1.2均值變化情況:對照組:與W0相比,W12時的MI均值 顯著下降,差異有統(tǒng)計學意義（P0.05）。于W12時,對照組中無改 善及輕度改善者各占 50%,而試驗組