下呼吸道解剖ppt課件

1、Anatomy of the Lower AirwayAnatomy of the Lower AirwayOcclusion of the bronchioleSmooth muscleForeign body (not shown)InflammationLung Volumes & CapacitiesTotal lung capacity (TLC) in a typical adult male is 6 litersMuch of inspired air does not enter alveoliTidal Volume (VT)volume of gas inhaled/ex

2、haled during a single ventilatory cycleUsually 5-7 cc/kg (typically 500 cc)Lung Volumes & CapacitiesDead Space Air (VD)Air remaining in air passageways, unavailable for gas exchange (usually 150 cc)Anatomic dead spacetracheabronchiPhysiologic dead spaceformed by factors like disease or obstructionEx

3、amples: COPD & atelectasisLung Volumes & CapacitiesMinute Volume Vmin(minute ventilation)amount of gas moved in and out of respiratory tract per minute(tidal volume - dead space volume) X RRFunctional Reserve Capacity (FRC)after optimal inspiration, the optimum amount of air that can be forced from

4、the lungs in a single exhalationLung Volumes & CapacitiesAlveolar Air (alveolar volume) VAAir reaching alveoli for gas exchangeUsually 350 ccInspiratory Reserve (IRV)Amount of gas that can be inspired in addition to tidal volumeExpiratory Reserve (ERV)Amount of gas that can be expired after a passiv

5、e (relaxed) expirationLung Volumes & CapacitiesVentilationDefined as movement of air into & out of lungsInspirationstimulus from respiratory center of brain (medulla)transmitted via phrenic nerve to diaphragmdiaphragm flattens during contractionintercostal muscles contractribs elevate and expandresu

6、lts in intrapulmonic pressure (pressure gradient)results in air being drawn into lungs & alveoli inflatedVentilationExpirationStretch receptors in lungs signal respiratory center via vagus nerve to inhibit inspirationHering-Breuer ReflexNatural elasticity of lungs passively expires air (in non-disea

7、sed lung)Control via PonsApneustic & Pneumotaxic centersVentilationChemoreceptorsCarotid bodies & Aortic archStimulated by PaO2, PaCO2 or pHPaCO2 considered normal neuroregulatory control of ventilationsHypoxic Drivedefault regulatory controlSenses changes in Pa02VentilationOther stimulations or depressants to ventilatory drivebody temp: w/ fever & w/hypothermiadrugs/meds: i