乳腺癌五或更長期的輔助內(nèi)分泌治療：一項已發(fā)表的隨機試驗的meta分析ppt課件講座

1、L/O/G/O煩惱有何懼怕，既然躲不掉，就調(diào)好心態(tài)與它共存。心向陽光，何懼風霜。煩惱有何懼怕，既然躲不掉，就調(diào)好心態(tài)與它共存。心向陽光，何懼風霜。茫茫人海你我相遇就是緣分，歡迎下載！茫茫人海你我相遇就是緣分，歡迎下載！乳腺癌五年或更長期的輔助內(nèi)分泌治療：乳腺癌五年或更長期的輔助內(nèi)分泌治療：一項已發(fā)表的隨機試驗的一項已發(fā)表的隨機試驗的metameta分析分析Fausto PetrelliBreast Cancer Res Treat 2013-6-2822021/8/12一、背景介紹一、背景介紹330%40%2021/8/12一、背景介紹一、背景介紹4 12000BC 5年年VS10年年TAM治

2、療治療中位隨訪中位隨訪13.6年：減少總生存及晚期年：減少總生存及晚期BC發(fā)生發(fā)生子宮內(nèi)膜癌發(fā)生風險子宮內(nèi)膜癌發(fā)生風險(3.1 vs. 1.6 %),死亡風險增加死亡風險增加0.2%。10年年TAM，減少，減少BC復(fù)發(fā)風險復(fù)發(fā)風險(P = 0.003), BC 相相關(guān)死亡風險關(guān)死亡風險 (P = 0.05) ，整體死亡風險，整體死亡風險 (P = 0.1), 第九年后的獲益更大。第九年后的獲益更大。5年年TAM 來曲唑來曲唑/安慰劑，安慰劑，64個月的中位隨訪中，個月的中位隨訪中，顯著降低復(fù)發(fā)風險，但顯著降低復(fù)發(fā)風險，但OS相近。相近。考慮了揭盲后，安慰劑組中考慮了揭盲后，安慰劑組中66%應(yīng)用

3、了來曲唑，提應(yīng)用了來曲唑，提示來曲唑顯著提高了示來曲唑顯著提高了DFS和和OS 。2021/8/12二、研究方法二、研究方法 1.數(shù)據(jù)來源5電子搜索2021/8/12二、研究方法二、研究方法 2.研究選擇/數(shù)據(jù)提取6入選標準入選標準提取數(shù)據(jù)提取數(shù)據(jù)早期乳腺癌患者早期乳腺癌患者RCT:比較比較5年及更久內(nèi)分泌治年及更久內(nèi)分泌治療療開始開始2013-6-11研究由兩名研究人員分別選擇，出現(xiàn)分歧時有第三名研究人員評議。研究由兩名研究人員分別選擇，出現(xiàn)分歧時有第三名研究人員評議。英文發(fā)表英文發(fā)表基本信息：雜志名、發(fā)表年份、作者名基本信息：雜志名、發(fā)表年份、作者名人口統(tǒng)計學：中位年齡、淋巴結(jié)水平、人口統(tǒng)

4、計學：中位年齡、淋巴結(jié)水平、月經(jīng)狀態(tài)、原發(fā)腫瘤的激素水平月經(jīng)狀態(tài)、原發(fā)腫瘤的激素水平研究信息：樣本量、研究設(shè)計、研究終點研究信息：樣本量、研究設(shè)計、研究終點治療方案治療方案結(jié)果結(jié)果 （率或事件數(shù)）：（率或事件數(shù)）：OS, 無復(fù)發(fā)生存無復(fù)發(fā)生存(RFS), 乳腺癌相關(guān)生存乳腺癌相關(guān)生存(BCSS), 非癌癥相關(guān)非癌癥相關(guān)死亡死亡, 局部或遠處的局部或遠處的 RFS (LR-RFS/D-RFS)人類研究人類研究2021/8/12二、研究方法二、研究方法72021/8/12三、結(jié)果三、結(jié)果82021/8/12三、結(jié)果三、結(jié)果92021/8/12三、結(jié)果三、結(jié)果102021/8/12三、結(jié)果三、結(jié)果1

5、12021/8/129、 人的價值，在招收誘惑的一瞬間被決定。22.3.722.3.7Monday, March 07, 202210、低頭要有勇氣，抬頭要有低氣。23:49:0523:49:0523:493/7/2022 11:49:05 PM11、人總是珍惜為得到。22.3.723:49:0523:49Mar-227-Mar-2212、人亂于心，不寬余請。23:49:0523:49:0523:49Monday, March 07, 202213、生氣是拿別人做錯的事來懲罰自己。22.3.722.3.723:49:0523:49:05March 7, 202214、抱最大的希望，作最大的努力

6、。2022年3月7日星期一下午11時49分5秒23:49:0522.3.715、一個人炫耀什么，說明他內(nèi)心缺少什么。2022年3月下午11時49分22.3.723:49March 7, 202216、業(yè)余生活要有意義，不要越軌。2022年3月7日星期一23時49分5秒23:49:057 March 202217、一個人即使已登上頂峰，也仍要自強不息。下午11時49分5秒下午11時49分23:49:0522.3.7三、結(jié)果三、結(jié)果13ER+2021/8/12三、結(jié)果三、結(jié)果14兩組中相似36%，P=0.0213%，P=0.022021/8/12三、結(jié)果三、結(jié)果152021/8/12四、討論四、討

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