Chapter14Tcellmediatedimmuneresponse學(xué)習(xí)教案

1、會計學(xué)1Chapter14TcellmediatedimmuneresponsecellsChapter 14 Chapter 14 T Cell Mediated Immune ResponseT Cell Mediated Immune Response（CMICMI）第1頁/共97頁第2頁/共97頁第3頁/共97頁第4頁/共97頁第5頁/共97頁第6頁/共97頁Lymph node, Spleen, MALT第7頁/共97頁被膜被膜輸出淋巴管輸出淋巴管Capture and presentation of exogenous Ags tissueLymphatic vesselDC an

2、tigenAfferentLymphatic vessel cortexLymph node 第8頁/共97頁第9頁/共97頁 CD4+T cell mediated immune response CD8+T cell mediated immune response第10頁/共97頁Cell surfacepeptidesof AgAntigens must be processed in orderto be recognised by T cellsYT T cellresponseNo T cellresponseNo T cellresponseNo T cellresponseN

3、o T cellresponseSolublenative AgCell surfacenative AgSoluble peptidesof AgCell surface peptides of Ag presented by cells that express MHC molecules第11頁/共97頁第12頁/共97頁第13頁/共97頁第14頁/共97頁第15頁/共97頁Three dimensional structure of TCR第16頁/共97頁Anatomical mechanism of TCR recognizes MHC/antigenic peptideMHC-a

4、 a helixAntigenic peptideCDR1CDR2CDR3CDR3CDR2CDR1TCR-b b chainTCR-a a chainMHC-a a helix第17頁/共97頁CDR3CDR2,1CDR1,2第18頁/共97頁第19頁/共97頁第20頁/共97頁第21頁/共97頁第22頁/共97頁第23頁/共97頁TCR complex第24頁/共97頁第25頁/共97頁The Two-Signal HypothesisCo-stimulatory signal(CD28/B7)第26頁/共97頁第27頁/共97頁第28頁/共97頁CD4MHC-IITCR/CD31ICAM-

5、1B7-1B7-2LFA-1LFA-1ICAM-3LFA-3B7-1CD28CD28LFA-1ICAM-3CD22Molecules associated with T activation Th cellAPCCTLA-4第29頁/共97頁第30頁/共97頁APCblock Tblock Th activityactivityDual signal model of Th cell activationIL-2RAPCThSignal 1Signal 2LPSTNF-a IL-1 IL-6IL-2ThSignal 1Th activatedactivatedCD28CD28B7第31頁/共9

6、7頁第32頁/共97頁第33頁/共97頁第34頁/共97頁第35頁/共97頁第36頁/共97頁TmEffector TProliferation of T cell第37頁/共97頁IL-12 IL- 4AgIL-23（IL-6，TGF-）Th17（IL-17）第38頁/共97頁n characteristic of memory T Cells (Tm): Long lived cells CD45RA-,CD45RO+ Easily triggered by low antigen Less dependent on co-stimulatory molecules Sensitive t

7、o CKs Responsible for maintaining immunological memory第39頁/共97頁第40頁/共97頁Days after immunityRatio of specific T cells in blood感應(yīng)階段Primary immunitySecondary immunity1/100001/10001/1000 7 14 21 28 35 42 Principle of T cell mediated immune responsecell mediated immune response Immunological memory第41頁/共

8、97頁第42頁/共97頁第43頁/共97頁第44頁/共97頁第45頁/共97頁（Th1，Tc）第46頁/共97頁第47頁/共97頁第48頁/共97頁第49頁/共97頁第50頁/共97頁第51頁/共97頁第52頁/共97頁第53頁/共97頁第54頁/共97頁Th1 cells. 第55頁/共97頁第56頁/共97頁第57頁/共97頁第58頁/共97頁nMHC restriction第59頁/共97頁第60頁/共97頁b b2mTCR-b b chainTCR-a a chain Homocysteine HLA-A68PeptideInteraction between TCR and homo

9、cysteine presented by HLA-A68 C第61頁/共97頁第62頁/共97頁第63頁/共97頁APC第64頁/共97頁Dual signal model of Tc activationTumor cellDCCD28CD28B7B7CD28第65頁/共97頁第66頁/共97頁第67頁/共97頁第68頁/共97頁第69頁/共97頁第70頁/共97頁第71頁/共97頁第72頁/共97頁第73頁/共97頁第74頁/共97頁第75頁/共97頁Normal cell No injury No injury第76頁/共97頁*Fas：Apo-1 or CD95第77頁/共97頁第78頁/共97頁 第79頁/共97頁CTL cellTarget cell第80頁/共97頁第81頁/共97頁第82頁/共97頁第83頁/共97頁第84頁/共97頁第85頁/共97頁第86頁/共97頁第87頁/共97頁第88頁/共97頁第89頁/共97頁NKTcells第90頁/共97頁第91頁/共97頁第92頁/共97頁第93頁/共97頁Superantige