Etimizol-Ethimizole-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEEtimizolCat. No.: HY-13918CAS No.: 64-99-3Synonyms: Ethimizole; Ethymisol; Ethymisole分式: CHNO分量: 210.23作靶點(diǎn): Others作通路: Others儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) Ethanol : 33.33 mg/mL (

2、158.54 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 4.7567 mL 23.7835 mL 47.5670 mL5 mM 0.9513 mL 4.7567 mL 9.5134 mL10 mM 0.4757 mL 2.3783 mL 4.7567 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請根據(jù)您的實(shí)驗(yàn)動物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實(shí)驗(yàn)結(jié)

3、果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% EtOH 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (11.89 mM); Clear solution2. 請依序添加每種溶劑： 10% EtOH 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (11.89 mM); Clear solution1/2 Master of Small Molecul

4、es 您邊的抑制劑師www.MedChemE3. 請依序添加每種溶劑： 10% EtOH 90% corn oilSolubility: 2.5 mg/mL (11.89 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Etimizol(Ethymisole; Antiffine; Ethylnorantifein) 可有效地作于缺氧造成的失憶癥。體內(nèi)研究 The time interval between administration ofetimizol (3 mg/kg) and the onset of learning varied between

5、 0.5and 3 h in the several series. Etimizol (Ethymisole) did not facilitate the learning in rats whatever the time ofadministration and biological modality of reinforcement 1. After administration of Etimizol (Ethymisole) atdoses of 10 or 1 mg/loop mean residence time of etimizol in the loop was 20.

6、1 and 7.6 min, respectively, withmean standard deviation being 3.1 and 0.8, respectively 2. Extracellular application of 5-10 mM/L Etimizol(Ethymisole) exerted a specific effect on the giant neurons of the Coretus corneus isolated nervous system:action potential duration increased significantly, spe

7、ed of development of its descending phase decreased,as well as the trace hyperpolarization amplitude 3.REFERENCES1. Borisova GIu. Effect of etimizol on instrumental learning in rats. Biull Eksp Biol Med. 1985 Jun;99(6):705-6.2. Trnovec T, et al. Etimizol absorption from the small intestine in dogs:

8、the dependence on dosage. Biull Eksp Biol Med. 1986Dec;102(12):729-30.3. Vislobokov AI, et al. Elektrophysiological parameters of mollusk neurons under the influence of etimizol. Fiziol Zh SSSR Im I MSechenova. 1975 Jun;61(6):917-24.McePdfHeightCaution: Product has not been fully validated for medical applications.Fo