NGI-1-ML414-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemENGI-1Cat. No.: HY-117383CAS No.: 790702-57-7Synonyms: ML414分式: CHNOS分量: 394.51作靶點: Others作通路: Others儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 160 mg/mL (405.57 mM; Need ultrasonic)Mas

2、s Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.5348 mL 12.6740 mL 25.3479 mL5 mM 0.5070 mL 2.5348 mL 5.0696 mL10 mM 0.2535 mL 1.2674 mL 2.5348 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百

3、分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.67 mg/mL (6.77 mM); Clear solution; Need warmingBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE物活性 NGI-1種細(xì)胞滲透性抑制劑。體外研究 NGI-1 blocks EGFR N-linked glycosylation in lung adenocarcinoma cells as assessed. In contr

4、ols EGFR isbiotinylated, consistent with its plasma membrane expression, but in NGI-1 treated cells the EGFR ispredominantly found in the non-biotinylated intracellular fraction suggesting a change in cellular localization 1.REFERENCES1. Lopez-Sambrooks C, et al. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat Chem Biol. 2016Dec;12(12):1023-1030.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;F