E3-ligase-Ligand-Linker-Conjugates-12 - E3 Ligase Ligand-Linker Conjugate - 生命科學試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEE3 ligase Ligand-Linker Conjugates 12Cat. No.: HY-103598CAS No.: 1797406-80-4分式: CHNOS分量: 645.77作靶點: E3 Ligase Ligand-Linker Conjugate作通路: PROTAC儲存式: Pure form -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗

2、DMSO : 50 mg/mL (77.43 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 1.5485 mL 7.7427 mL 15.4854 mL5 mM 0.3097 mL 1.5485 mL 3.0971 mL10 mM 0.1549 mL 0.7743 mL 1.5485 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 E3 ligase Ligand-Linker Conjugates 12于 P

3、ROTAC 技術(shù)的化合物，其結(jié)合了E3連接酶配體和連接橋。IC50 & Target VHL體外研究E3 ligase Ligand-Linker Conjugates 12 is extracted from patent WO/2016/146985A1, figure 11. PROTAC hasbeen developed having structure A-L-B that can tether a bromodomain inhibitor via a moiety which binds to aprotein within the bromo- and Extra-termi

4、nal (BET) family of proteins to a small molecule E3 ubiquintin ligase1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEprotein binding ligand compond via a suitable linker 1 2.REFERENCES1. CIULLI, Alessio, et al. DERIVATIVES OF 1-(CYCLOPENTYL OR 2-PYRROLIDINYL)CARBONYLAMINOMETHYL-4-(1,3-THIAZOL-5-YL)

5、 BENZENE WHICH ARE USEFUL FOR THE TREATMENT OF PROLIFERATIVE, AUTOIMMUNE OR INFLAMMATORY DISEASES.WO2016146985A1.2. Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015 Aug21;10(8):1770-7.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-5