Valacyclovir-hydrochloride-Valaciclovir-hydrochloride-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEValacyclovir hydrochlorideCat. No.: HY-17425ACAS No.: 124832-27-5Synonyms: Valaciclovir hydrochloride分式: CHClNO分量: 360.8作靶點: HSV作通路: Anti-infection儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 D

2、MSO : 25 mg/mL (69.29 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.7716 mL 13.8581 mL 27.7162 mL5 mM 0.5543 mL 2.7716 mL 5.5432 mL10 mM 0.2772 mL 1.3858 mL 2.7716 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內實驗請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄的儲備液，再依次添加助溶?為保證實驗結果的可靠性，體內實

3、驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.93 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (6.93 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oil1/2 M

4、aster of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (6.93 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Valacyclovir鹽酸鹽抗HSV化合物。REFERENCES1. Valacyclovir. New indication: for genital herpes, simpler administration. Can Fam Physician. 1999 Jul;45:1698-700, 1703-5.2. Lycke J, et al. Acyclovir

5、 levels in serum and cerebrospinal fluid after oral administration of valacyclovir. Antimicrob Agents Chemother.2003 Aug;47(8):2438-41.3. Comparison of efficacies of famciclovir and valaciclovir against herpes simplex virus type 1 in a murineimmunosuppression model.Antimicrob Agents Chemother. 1995

6、May;39(5):1114-9.4. Dhaliwal DK, Romanowski EG, Yates KA, Valacyclovir inhibits recovery of ocular HSV-1 after experimental reactivation by excimer laserkeratectomy. Cornea. 1999 Nov;18(6):693-9.5. Guo A, Hu P, Balimane PV, Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1)expressed in a mammalian cell line.J Pharmacol Exp Ther. 1999 Apr;289(1):448-54.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.T