肝膽疾病研究團(tuán)隊(duì)

1、PAGE PAGE 3肝膽疾病研究團(tuán)隊(duì)一、團(tuán)隊(duì)負(fù)責(zé)人代榮陽 博士，教授，碩士生導(dǎo)師，澳門科技大學(xué)兼職博士生導(dǎo)師，哈佛醫(yī)學(xué)院訪問學(xué)者，教育部新世紀(jì)優(yōu)秀人才支持計(jì)劃獲得者，四川省學(xué)術(shù)技術(shù)帶頭人后備人選。二、團(tuán)隊(duì)主要人員代榮陽博士；趙曉芳博士；周虹博士；成鷹博士；姚富麗博士；李玉筱博士；甘淋博士；劉秋均博士；等。三、研究方向研究團(tuán)隊(duì)致力于肝膽疾病細(xì)胞信號(hào)調(diào)控研究，目前主要從事應(yīng)激反應(yīng)與肝膽疾病的關(guān)系研究。四、主要論文（*，通訊作者；+并列第一）01Feng C, He K, Zhang C, Su S, Li B, Li Y, Duan CY, Chen S, Chen R, Liu Y, Li H

2、, Wei M, Xia X, Dai R*. JNK Contributes to the Tumorigenic Potential of Human Cholangiocarcinoma Cells through the mTOR Pathway Regulated GRP78 Induction. PLoS One. 2014;9(2):e90388. 02RY Dai, XF Zhao, JJ Li, R Chen, ZL Luo, LX Yu, SK Chen, CY Zhang, CY Duan, YP Liu, CH Feng, XM Xia, H Li, J Fu, HY

3、Wang*. Implication of transcriptional repression in compound C-induced apoptosis in cancer cells. Cell Death Dis. 2013;4:e883. 03Chen R, Duan CY, Chen SK, Zhang CY, He T, Li H, Liu YP, Dai RY*. The suppressive role of p38 MAPK in cellular vacuole formation. J Cell Biochem. 2013;114:1789-99. 04Chen R

4、, Li J, Feng C, Chen S, Liu Y, Duan C, Li H, Xia X, He T, Wei M, Dai R*. c-Met function requires N-linked glycosylation modification of pro-Met. J Cell Biochem. 2013;114(4):816-22. 05Dai R, Li J, Fu J, Chen Y, Wang R, Zhao X, Luo T, Zhu J, Ren Y, Cao J, Qian Y, Li N, Wang H*. The Tyrosine Kinase c-M

5、et Contributes to the Pro-tumorigenic Function of the p38 Kinase in Human Bile Duct Cholangiocarcinoma Cells. J Biol Chem. 2012;287(47):39812-23. 06Dai R, Li J, Fu J, Chen Y, Yu L, Zhao X, Qian Y, Zhang H, Chen H, Ren Y, Su B, Luo T, Zhu J, Wang H*. Disturbance of Ca2+ homeostasis converts pro-Met i

6、nto non-canonical tyrosine kinase p190MetNC in response to endoplasmic reticulum stress in MHCC97 cells. J Biol Chem. 2012;287(18):14586-97. 07Dai R, Yan D, Li J, Chen S, Liu Y, Chen R, Duan C, Wei M, Li H*, He T. Activation of PKR/eIF2 signaling cascade is associated with dihydrotestosterone-induce

7、d cell cycle arrest and apoptosis in human liver cells. J Cell Biochem. 2012;113(5):1800-8. 08Run Chen, Rongyang Dai +, Chunyan Duan, Youping Liu, Shaokun Chen, Dongmei Yan, Chuanning Chen, Mei Wei, Hong Li*. Unfolded Protein Response Suppresses Cisplatin-induced Apoptosis via Autophagy Regulation i

8、n Human Hepatocellular Carcinoma Cells. Folia Biol (Praha). 2011;57(3):87-95. 09Liu Y, Liu P, Dai R+, Wang J, Zheng Y, Shen J, Guo F, Wang L, Li H, Wei M*. Analysis of plasma proteome from cases of the different traditional Chinese medicine syndromes in patients with chronic hepatitis B. J Pharm Bio

9、med Anal. 2012;59:173-8. 10Rongyang Dai, Juan Li, Youping Liu, Dongmei Yan, Shaokun Chen, Chunyan Duan, Xiaoyan Liu, Tao He, Hong Li*. MiR-221/222 suppression protects against endoplasmic reticulum stress-induced apoptosis via p27Kip1- and MEK/ERK-mediated cell cycle regulation. Biol Chem. 2010;391(

10、7):791-801. 11Rongyang Dai, Shaokun Chen, Dongmei Yan, Run Chen, Youping Liu, Chunyan Duan, Juan Li, Tao He, Hong Li*. PI3K/Akt promotes GRP78 accumulation and inhibits endoplasmic reticulum stress-induced apoptosis in HEK293 cells. Folia Biol(PRAHA). 2010;56(2):37-46. 12Rong-Yang Dai, Yao Chen, Jin

11、g Fu, Li-Wei Dong, Yi-Bin Ren, Guang-Zhen Yang, You-Wen Qian, Jie Cao, Shan-Hua Tang, Sheng-Li Yang and Hong-Yang Wang*. p28GANK inhibits endoplasmic reticulum stress-induced cell death via enhancement of the endoplasmic reticulum adaptive capacity. Cell Res. 2009;19(11):1243-57. 13Dai R, Chen R, Li

12、 H*. Cross-talk between PI3K/Akt and MEK/ERK pathways mediates endoplasmic reticulum stress-induced cell cycle progression and cell death in human hepatocellular carcinoma cells. Int J Oncol. 2009;34(6):1749-57. 14Zhang HL, Yu LX, Yang W, Tang L, Lin Y, Wu H, Zhai B, Tan YX, Shan L, Liu Q, Chen HY,

13、Dai RY, Qiu BJ, He YQ, Wang C, Zheng LY, Li YQ, Wu FQ, Li Z, Yan HX, Wang HY*. Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats. J Hepatol. 2012;57(4):803-12. 15Cao J, Chen Y, Fu J, Qian YW, Ren YB, Su B, Luo T, Dai RY, Huang L, Y

14、an JJ, Wu MC, Yan YQ, Wang HY*. High Expression of Proline-Rich Tyrosine Kinase2 is Associated with Poor Survival of Hepatocellular Carcinoma via Regulating Phosphatidylinositol 3-Kinase/AKT Pathway. Ann Surg Oncol. 2013; 20(Suppl 3):S312-23. 16Qian YW, Chen Y, Yang W, Fu J, Cao J, Ren YB, Zhu JJ, S

15、u B, Luo T, Zhao XF, Dai RY, Li JJ, Sun W, Wu MC, Feng GS, Wang HY*. p28GANK prevents degradation of Oct4 and promotes expansion of tumor-initiating cells in hepatocarcinogenesis. Gastroenterology. 2012;142(7):1547-58. 17Li-wei Dong, Guang-zhen Yang, Yu-fei Pan, Yao Chen, Ye-xiong Tan, Rong-yang Dai

16、, Yi-bin Ren, Jing Fu, Hong-yang Wang*. The oncoprotein p28GANK establishes a positive feedback loop in -catenin signaling. Cell Res. 2011;21(8):1248-61. 18馮春紅,陳潤(rùn),陳紹坤,李娟,段春燕,劉友平,李洪,代榮陽*. 真核起始因子2的磷酸化抑制順鉑介導(dǎo)的肝癌 細(xì)胞凋亡.中華肝臟病雜志, 2013;21(04):290-4. (Medline收錄)19Zhao X, Fu J, Xu A, Yu L, Zhu J, Dai R, Su B,

17、Luo T, Li N, Qin W, Wang B, Jiang J, Li S, Chen Y, Wang H. Gankyrin drives malignant transformation of chronic liver damage-mediated fibrosis via the Rac1/JNK pathway. Cell Death Dis. 2015;6:e1751.20 Luo T, Fu J, Xu A, Su B, Ren Y, Li N, Zhu J, Zhao X, Dai R, Cao J, Wang B, Qin W, Jiang J, Li J, Wu

18、M, Feng G, Chen Y, Wang H. PSMD10/Gankyrin Induces Autophagy to Promote Tumor Progression through Cytoplasmic Interaction with ATG7 and Nuclear Transactivation of ATG7 Expression. Autophagy. 2016 ;12(8):1355-71.21 Du J, Tao ZH, Li J, Liu YK, Gan L. Construction of a hepatocellular carcinoma cell lin

19、e that stably expresses stathmin with a Ser25 phosphorylation site mutation. Genet Mol Res. 2015,14(4):12111-12117.（IF:0.764）22 Guo K, Gan L, Zhang S, Cui FJ, Cun W, Li Y, Kang NX, Gao MD, Liu KY.Translocation of HSP27 into liver cancer cell nucleus may be associated with phosphorylation and O-GlcNA

20、c glycosylation. Oncol Rep. 2012 ,28(2):494-500.（IF:2.486）23Gong S, Tao Z, Liu X, Gan L . An underlying prognosis predictor of hepatocellular carcinoma: Oncoprotein 18. Biomed Rep. 2014,2(1):85-88.24 Fuli Yao, Yazhen Liu, Linyong Du, Xinyan Wang, Anying Zhang, He Wei, Hong Zhou*. Molecular identific

21、ation of transcription factor Runx1 variants in grass carp (Ctenopharyngodon idella) and their responses to immune stimuli. Vet Immunol Immunopathol. 2014,160 (3-4):201-208. (IF: 1.748 ) 25 Fuli Yao, Xiao Yang, Xinyan Wang, He Wei, Anying Zhang, Hong Zhou*. Molecular and functional characterization of an IL-1 receptor antagonist in grass carp (Ctenopharyngodon idella). Dev Comp Immunol. 2015,49(2):207-216. (IF: 3.62 )26 Cheng Y,Kuang W,Hao Y,Zhang D,Lei M,Du