生命科學(xué)與技術(shù)學(xué)院

生命科學(xué)與技術(shù)學(xué)院國(guó)際一流水平研究生課程簡(jiǎn)介課程名稱：高級(jí)生物材料學(xué)課程代碼：170.610課程類型：□一級(jí)學(xué)科基礎(chǔ)課■二級(jí)學(xué)科基礎(chǔ)課□其它：考核方式：考試教學(xué)方式：講授適用專業(yè)：理工醫(yī)適用層次：■碩士■博士開課學(xué)期：秋季總學(xué)時(shí)：32學(xué)分：2先修課程要求：無(wú)機(jī)化學(xué)、有機(jī)化學(xué)、生物材料學(xué)課程組教師姓名職稱專業(yè)年齡學(xué)術(shù)方向張勝民教授生物醫(yī)學(xué)工程49生物材料MyronSpector(美國(guó)哈佛醫(yī)學(xué)院)教授、美國(guó)生物材料學(xué)會(huì)前主席生物材料62生物材料TonyMikos（美國(guó)Rice大學(xué)）教授TissueEngineer主編組織工程50組織工程In-SeopLee（韓國(guó)延世大學(xué)）教授BiomedMater主編生物材料53生物材料表面工程周磊副教授生物材料33生物仿生材料馬軍副教授生物材料32納米生物材料課程負(fù)責(zé)教師教育經(jīng)歷及學(xué)術(shù)成就簡(jiǎn)介：張勝民：武漢理工大學(xué)材料學(xué)專業(yè)生物醫(yī)學(xué)材料方向工學(xué)博士?，F(xiàn)任華中科技大學(xué)先進(jìn)生物材料與組織工程交叉學(xué)科中心教授、博士生導(dǎo)師、主任；GuestEditorandBoardMemberofBiomedicalMaterials(IOP,UK)；NSFC-KOSEF中韓生物材料與納米生物技術(shù)研究中心創(chuàng)始主席（FoundingChair）；第5屆、第6屆及第9屆中韓生物材料與納米生物技術(shù)研討會(huì)大會(huì)主席[NSFC、KOSEF（NRF）、教育部國(guó)際合作司]；第9屆世界生物材料大會(huì)醫(yī)用復(fù)合材料分會(huì)主席、2012世界生物物理與醫(yī)學(xué)工程大會(huì)組織工程框架分會(huì)主席、中國(guó)生物制造學(xué)會(huì)（CBMS）常務(wù)理事兼生物材料專業(yè)會(huì)員會(huì)副主任委員；第三屆亞洲生物材料大會(huì)國(guó)際顧問(wèn)委員會(huì)成員等。2002以來(lái)先后在KyotoU、TokyoDenkiU、YonseiU、MIT作學(xué)術(shù)訪問(wèn)與合作研究。先后主持科技部政府間國(guó)際科技合作項(xiàng)目、NSFC-KOSEF國(guó)際合作項(xiàng)目及NSFC-NRF國(guó)際合作項(xiàng)目6項(xiàng)；主持國(guó)家863計(jì)劃項(xiàng)目、國(guó)家973計(jì)劃項(xiàng)目、國(guó)家科技支撐計(jì)劃項(xiàng)目、國(guó)家自然科學(xué)基金項(xiàng)目等17項(xiàng)。在國(guó)際、國(guó)內(nèi)重要學(xué)術(shù)刊物等發(fā)表論文100余篇（部分論文并被NatureMaterials、ProgressinPolymerScience、AccountsofChemicalResearch、ACSnano等高水平期刊正面引用）；以第一發(fā)明人申請(qǐng)國(guó)家發(fā)明專利30余項(xiàng)，獲專利授權(quán)15項(xiàng)，國(guó)際（PCT）專利及美國(guó)專利3項(xiàng)，部分成果投入應(yīng)用產(chǎn)生較大社會(huì)經(jīng)濟(jì)效益。主要研究方向：再生醫(yī)學(xué)材料；生物材料先進(jìn)制造；組織器官工程。課程教學(xué)目標(biāo)：幫助學(xué)生獲得生物材料的分子設(shè)計(jì)與合成、天然生物材料結(jié)構(gòu)與仿生制備、生物材料與組織相互作用、納微米載體等專業(yè)基本知識(shí)，掌握生物材料學(xué)發(fā)展的前沿動(dòng)態(tài)，為從事生物材料研究和相關(guān)專業(yè)工作奠定堅(jiān)實(shí)的基礎(chǔ)。課程大綱：第一章概論第二章生物材料的分類與性質(zhì)§2.1合成高分子§2.2金屬生物材料§2.3陶瓷生物材料§2.4碳材料§2.5天然生物材料第三章血液相容性與血管移植物§3.1血液相容性§3.2血管移植物第四章蛋白與表面§4.1蛋白吸附§4.2表面設(shè)計(jì)§4.3細(xì)胞粘附調(diào)控第五章炎癥與異體反應(yīng)§5.1定義§5.2急性炎癥§5.3慢性炎癥第六章控釋與生物材料§6.1可控藥物釋放系統(tǒng)§6.2注射與移植§6.3經(jīng)皮§6.4其他第七章生物力學(xué)與外科植入物§7.1外科與關(guān)節(jié)置換§7.2植入物的力學(xué)性能第八章生物表面改性與表征第九章回顧與討論教材：《BiomaterialsScience:AnIntroductiontoMaterialsinMedicine》BuddyD.Ratner,AllanS.Hoffman,FrederickJ.Schoen,JackE.Lemons，SanDiegoCA:Elsevier,2004.主要參考書：1.《Biomaterials》JoyceY.Wong,JosephD.Bronzino,CRCPress,2006.2.《AManualforBiomaterials/ScaffoldFabricationTechnology》Jan-ThorstenSchantzeds.WorldScientific，2007本課程達(dá)到國(guó)際一流水平研究生課程水平的標(biāo)志：師資方面：課程組由張勝民教授牽頭，邀請(qǐng)美國(guó)哈佛醫(yī)學(xué)院的MyronSpector教授，Rice大學(xué)的TonyMikos教授，韓國(guó)延世大學(xué)的In-SeopLee教授前來(lái)教授，這幾位教授是當(dāng)今世界上在生物材料領(lǐng)域最為活躍的科學(xué)家，Spector教授和Lee教授是知名國(guó)際學(xué)術(shù)期刊BiomedicalMaterials的主編，Mikos教授是國(guó)際知名學(xué)術(shù)期刊TissueEngineering的主編，他們前來(lái)華中科技大學(xué)生物醫(yī)學(xué)工程系講學(xué)，將給學(xué)生帶來(lái)最前沿的科研動(dòng)態(tài)和最先進(jìn)的科學(xué)理念，幫助研究生快速成長(zhǎng)，與世界先進(jìn)研究水平接軌。此外，本課程還有周磊和馬軍兩位青年教師作為后備力量，為本課程的順利開展提供充分保障。教學(xué)內(nèi)容方面：本課程所講授的內(nèi)容涉及了生物材料領(lǐng)域的前沿?zé)狳c(diǎn)問(wèn)題，例如新型高分子植入材料的生物相容性、生物材料的表面工程，生物材料與人體免疫系統(tǒng)的相互作用等。這些內(nèi)容將根據(jù)最新研究成果整理匯集成專題，不僅使研究生盡快熟悉本學(xué)科必需的基礎(chǔ)專業(yè)知識(shí)，而且也掌握了當(dāng)前該領(lǐng)域的最新研究成果。教學(xué)內(nèi)容將更多的采用案例模式，以點(diǎn)帶面，讓學(xué)生從案例中學(xué)到科學(xué)規(guī)律，并在案例的解讀中，著力培養(yǎng)學(xué)生的創(chuàng)新思維。教學(xué)方式方面：結(jié)合基礎(chǔ)知識(shí)和應(yīng)用案例，圍繞一些專門主題，進(jìn)行專題研究和討論。課堂形式包括講授、小組討論、案例辯論等。尤其是案例辯論方案，是參考目前在麻省理工學(xué)院等知名大學(xué)的成功經(jīng)驗(yàn)，開展的新型教學(xué)形式，將目前國(guó)際上爭(zhēng)論的熱點(diǎn)科學(xué)問(wèn)題提出來(lái)，并提供相關(guān)閱讀材料，在研究生課外閱讀后，經(jīng)過(guò)課堂初次講演后，切分成2個(gè)或者更多小組，分別為自己主張的學(xué)術(shù)觀點(diǎn)進(jìn)行自由辯論，教師在其中起到組織和引導(dǎo)作用，這種教學(xué)方式旨在充分調(diào)動(dòng)學(xué)生的開放思維，這有別于過(guò)去讓學(xué)生單純讀文獻(xiàn)講報(bào)告的形式，將極大的調(diào)動(dòng)學(xué)生學(xué)習(xí)的積極性，也可以讓學(xué)生更多的了解科學(xué)研究進(jìn)展以及相關(guān)知識(shí)。教材方面：本課程選用Elsevier出版社出版的《BiomaterialsScience:AnIntroductiontoMaterialsinMedicine》，這本書出版以來(lái)，被諸多知名美國(guó)大學(xué)選作生物材料課程的教材，該書內(nèi)容詳盡，涵蓋了生物材料學(xué)涉及的諸多專題，書中既有基礎(chǔ)知識(shí)要點(diǎn)，也有不少應(yīng)用案例匯編，對(duì)于不同層次的學(xué)習(xí)者都有很大的參考價(jià)值。另外兩本參考書，與教材互為補(bǔ)充，分別從基礎(chǔ)知識(shí)和應(yīng)用技術(shù)兩個(gè)方面對(duì)生物材料學(xué)進(jìn)行論述，讓學(xué)生在閱讀后，不僅掌握基礎(chǔ)知識(shí)，而且能夠在試驗(yàn)中加以應(yīng)用書中提到的相關(guān)技術(shù)，提高相關(guān)的實(shí)驗(yàn)技能和設(shè)計(jì)能力。此外，本課程還將提供一些相關(guān)案例的閱讀材料，提高研究生提高科研能力，接觸最前沿的科研動(dòng)態(tài)。其它：為了使本學(xué)科的研究生能夠盡快和國(guó)際接軌，并且提高英文論文的閱讀和寫作能力，本課程聘請(qǐng)的三位海外教授，將從如何撰寫科學(xué)論文的角度，提供一些咨詢服務(wù)，幫助研究生從設(shè)計(jì)試驗(yàn)之初，就有一個(gè)完整的思路，能夠有條理的整理科學(xué)實(shí)驗(yàn)數(shù)據(jù)，更早的發(fā)表高水平科學(xué)論文。SyllabusofWorld-classGraduateCoursesinCollegeofLifeScienceandTechnologyCourseName：AdvancedBiomaterialsCourseCode：170.610CourseType：□FundamentalCoursefor1stLevelDisciplines■FundamentalCoursefor2ndLevelDisciplines□Others：Assessment:ExaminationTeachingFormat:LectureForMajors：Science,Engineering,MedicalLevel：Level：■MSc■PhDSemester：FallCreditHours：32Credits：2PrerequisiteCourses:Inorganicchemistry,organicchemistry,BiomaterialsscienceTeachersTitleMajorAgeResearchInterestsShengminZhangProf.BiomedicalEngineering49BiomaterialsMyronSpector(HarvardMedicalSchool，U.S.A.)Prof.Biomaterials62BiomaterialsTonyMikos(RiceUniv.，U.S.A.）Prof.Biomaterials50TissueEngineeringIn-SeopLee（YonseiUniversity,Korea）Prof.Biomaterials53BiomaterialsandSurfaceEngineeringLeiZhouAssociateProf.Biomaterials33Bio-mimeticmaterialsJunMaAssociateProf.Biomaterials32BiomaterialsCVoftheCoursePrincipalInstructorShengminZhang:Ph.DinMaterialsScience(BiomedicalMaterials)receivedfromWuhanUniversityofTechnology.NowheisaProfessorandHeadAdvancedBiomaterialsandTissueEngineeringCenter,HuazhongUniversityofScienceandTechnology(HUST)&FoundingChairofChina-KoreaCenterforBiomaterialsandNano-biotechnologyAdd:LifeScienceBuilding,1037LuoyuRd.,430074Wuhan,P.R.ChinaTel:+862787792216;Fax:+862787792205E-mail:smzhang@Dr.ShengminZhang’sresearchinterestsarefocusedonbiomaterialsfortissueengineeringandregenerativemedicine,includingnano-Ca-P(Si)biomaterialsforhardtissuerepair,absorbablepolymeranditscomposite/hybridmaterialsforinternalfixation,bioactivecoating,bio-or/anddigital-fabricationfortissueengineeringscaffolds,imagingofnano-biomaterials,tissueengineering(boneandcartilage,bloodvessel,myocardial,etc.),bio-mimeticandtemplateco-assemblynano-biomaterials,material-cell/tissueinteractionandmechanisminmolecularlevel.AsaPI,hehascompletedmorethan20keyprojectsonadvancedbiomaterialsfromNSFC,MOST,MOEandthelocalgovernments,etc.Heisanauthororco-authorofabout100peer-reviewedpapersand5books.Atthesametime,heistheinventorofmorethan30patents.ProfessorShengminZhangisanactivescientistinbiomaterialsfields.Hechairedseveralinternationalconferencesandsymposiums,andwasdesignatedaskeynoteorinvitedspeakerinabout30symposiumsandmeetings.Currently,heisanExecutiveDirectorofChineseBio-manufacturingSociety(CBMS)andtheViceDirectorofBiomaterialsCommittee,CBMS.HealsoistheEditorialMemberofseveralinternationaljournals,includingBiomedicalMaterials(IOP),FrontiersofMaterialsScience,Springer-Linketc.ProfessorZhangistheFoundingChairofChina-KoreaCenterforBiomaterialsandNano-BiotechnologysupportedbyNSFC,KOSEFandMinistryofEducationofP.R.China.OtherProfessionalContributionsDirector,China’sDelegationofScienceandTechnologytoKorea,designatedbytheMinistryofScienceandTechnologyofP.R.ChinaChairman,the6thKorea-ChinaSymposiumonBiomaterialsandNano-BioTechnology,supportedbyNationalNaturalScienceFoundationofChina,KoreanScienceandEngineeringFoundationandMinistryofEducationofP.R.China2007-10Chairman,the5thChina-KoreaSymposiumonBiomaterialsandNano-BioTechnology,supportedbyNationalNaturalScienceFoundationofChina,KoreanScienceandEngineeringFoundationandMinistryofEducationofP.R.China2005-ExecutiveDirectorofChineseBio-manufacturingSociety(CBMS)andtheViceDirectorofBiomaterialsCommittee,CBMS2010-2013EditorialMemberofBiomedicalMaterials,IOP,UK2010-2013EditorialMemberofFrontiersofMaterialsScience,Springer-Link2011-12Chairman,the9thChina-KoreaSymposiumonBiomaterialsandNano-BioTechnology,supportedbyNationalNaturalScienceFoundationofChina,NRFandMinistryofEducationofP.R.China2012-5Chairman,SessionofScaffoldsinTissueEngineering,2012WorldCongressonBiophysicsandMedicalEngineering,Beijing2012-6Chairman,SessionofMedicalComposites,The9thWorldBiomaterialsCongress,Chengdu.ChinaCourseObjectives：Thiscourseisdesignedtointroducestudentstothevariousclassesofbiomaterialsinuseandtheirapplicationinselectedsubspecialtiesoftissueengineeringandregenerativemedicine.Thelecturesinvolvedwithmoleculardesignandsynthesisofbiomaterials,thestructureofnaturalbiomaterialsandbio-mimeticfabrication,interactionbetweenbiomaterialsandtissues,nano-/micro-carriers,andotherresearchfieldsrelatedtobiomaterials.CourseOutline:Chapter1IntroductiontoBiomaterialsChapter2Biomaterials:TypesandProperties§2.1Syntheticpolymer§2.2Metallicbiomaterials§2.3Ceramicbiomaterials§2.4Carbonbiomaterials§2.5NaturalbiomaterialsChapter3BloodCompatibilityandvascularprostheses§3.1BloodCompatibility§3.2VascularProsthesesChapter4Proteinatsurfaces§4.1Proteinadsorption§4.2Surfacedesign§4.3CelladhesioncontrolChapter5InflammationandtheForeignBodyReaction§5.1GeneralDefinitions§5.2AcuteInflammation§5.3ChronicInflammationChapter6ControlledreleaseandBiomaterials§6.1Controlleddrugdeliverysystem(DDS)§6.2InjectionandImplants§6.3Transdermal§6.4OthersChapter7Biomechanicsandorthopedicimplants§7.1Orthopedics&JointReplacement§7.2BiomechanicalConsiderationsforImplantsChapter8Bio-surface:surfacemodificationandanalysisChapter9ReviewandSeminarTextbook:《BiomaterialsScience:AnIntroductiontoMaterialsinMedicine》BuddyD.Ratner,AllanS.Hoffman,FrederickJ.Schoen,JackE.Lemons，SanDiegoCA:Elsevier,2004.References:1.《Biomaterials》JoyceY.Wong,JosephD.Bronzino,CRCPress,2006.2.《AManualforBiomaterials/ScaffoldFabricationTechnology》Jan-ThorstenSchantzeds.WorldScientific，2007FeaturesasaWorld-classGraduateCourse:1.Teacher'sQualifications:ThiscourseisorganizedbyProf.ShengminzhangwhoistheteamleaderofAdvancedcenterofbiomaterialsandtissueengineeringinHuazhongUniversityofScienceandTechnology.Heisalsoinchargeofsub-ordinarydisciplineofbiomaterialsandtissueengineeringinthedepartmentofbiomedicalengineering.Prof.ZhanginvitesProf.MyronSpector(Harvardmedicalschool,USA),Prof.TonyMikos(RiceUniversity,USA)andProf.In-SeopLee(YonseiUniversity,Korea).TheseprofessorsfromoverseasarefamousscientistsinthefieldofBiomaterials.Prof.SpectorandProf.Leearethechiefeditorsofthejournal:BiomedicalMaterials.Prof.Mikosisthechiefeditorofthejournal:Tissueengineering.Thesejournalsaretheleadingjournalsinthefieldofbiomaterialsandtissueengineering.Thethreeprofessorswillbringtheirforefrontstudiesandadvancedscientificideastoourpostgraduatestudents,helpthemcatchuptheword-classresearchlevel.Inaddition,thiscoursewillbeassistedbytwoassociateprofessorsintheteam,Dr.ZhouandDr.Ma,whowillsupportandguaranteethecourseimplementation.2.Coursecontents:Thiscoursecoversthehotissuesinthefieldofbiomaterialsnowadays.Accordingtothenewestresearchreports,thelecturerswillhelpthepostgraduatestudentsnotonlyunderstandthebasicknowledgeofbiomaterialsscience,butalsoknowthelatestscientificachievements.Theteachingcontentsaremostlyincase-studies.Thescientificideasandrulesareconcludedfromthecases.Thiscoursewillstrengthenthesenseofinnovationofthepostgraduatestudentinvolvedintheclass.3.TeachingFormat:Theteachingmethodsarecombinedwithlectures,case-studies,groupdiscussionanddebate.Intheclass,thelecturersfocusonsomehottopicsandorganizethereadinganddiscussions.ForthegroupdebatemodewhichisverypopularinthefamousuniversitieslikeMITinUSA,thelecturersintroducethecontroversialhotissuestothestudentsandassignthereadings.Afterashortpresentationbythestude