Mepivacaine-DataSheet-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemEMepivacaineCat.No.:HY-B0517CASNo.:96-88-8分?式:C??H??N?O分?量:246.35作?靶點:SodiumChannel作?通路:MembraneTransporter/IonChannel儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數據體外實驗DMSO:33.33mg/mL(135.30mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM4.0593mL20.2963mL40.5927mL5mM0.8119mL4.0593mL8.1185mL10mM0.4059mL2.0296mL4.0593mL請根據產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存?式和期限。BIOLOGICALACTIVITY?物活性Mepivacaine?種酰胺型藥劑，可暫時使局部失去知覺。Mepivacaine與神經元細胞膜上特定的電壓門控鈉離?通道結合，抑制鈉離?內流和膜去極化。體外研究Mepivacainebindstospecificvoltage-gatedsodiumionchannelsinneuronalcellmembranes,whichinhibitsbothsodiuminfluxandmembranedepolarization.Thisleadstoablockageofnerveimpulseinitiationandconductionandresultsinareversiblelossofsensation.Comparedtootherlocalanesthetics,thisagenthasamorerapidonsetandmoderatedurationofaction[2].1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemEMepivacainehasareasonablyrapidonset(morerapidthanthatofprocaine)andmediumdurationofaction(shorterthanthatofprocaine)[3].Mepivacainedisplaysapreferentialuse-dependentblockofNa(v)1.8,S(-)-bupivacainedisplaysapreferenceforTTXsNa(+)channels[4].REFERENCES[1].FroehleM,etal.ECMOforCardiacRescueafterAccidentalIntravenousMepivacaineApplication.CaseRepPediatr.2012;2012:491692.[2].mepivacainehydrochloride.[3].Burm,A.G.,etal.,Pharmacokineticsoftheenantiomersofmepivacaineafterintravenousadministrationoftheracemateinvolunteers.AnesthAnalg,1997.84(1):p.85-9.[4].Leffler,A.,J.Reckzeh,andC.Nau,BlockofsensoryneuronalNa+channelsbythesecreolyticambroxolisassociatedwithaninteractionwithlocalanestheticbindingsites.EurJPharmacol,2010.630(1-3):p.19-28.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.