Ezeprogind-AZP-2006-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEEzeprogindCat.No.:HY-109172CASNo.:615539-20-3Synonyms:AZP-2006分?式:C??H??N?分?量:428.66作?靶點(diǎn):Amyloid-β作?通路:NeuronalSignaling儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:20.83mg/mL(48.59mM;ultrasonicandwarmingandheatto70°C)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.3329mL11.6643mL23.3285mL5mM0.4666mL2.3329mL4.6657mL10mM0.2333mL1.1664mL2.3329mL體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.08mg/mL(4.85mM);Clearsolution2.請(qǐng)依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.08mg/mL(4.85mM);Clearsolution3.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(4.85mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性Ezeprogind(AZP-2006)?種具有?服活性神經(jīng)營(yíng)養(yǎng)誘導(dǎo)劑(neurotrophicinducer)。Ezeprogind針對(duì)所有神經(jīng)退?性變的原因，?不僅僅針對(duì)標(biāo)記物，如Abeta蛋?或tau蛋?。Ezeprogind?種有效的神經(jīng)保護(hù)劑(neuroprotectant)，可?于神經(jīng)疾病的研究，包括進(jìn)?性核上?痹(PSP)、Tau蛋?病變、阿爾茨海默病和帕?森病等。IC50&TargetIC50:allcausesofneurodegeneration[1]REFERENCES[1].AlzprotectStrengthensItsIntellectualPropertyPortfolioforItsFirst-in-ClassClinicalStageDrugEzeprogind[2].AStudytoAssessTolerability,Safety,PharmacokineticsandEffectofAZP2006inPatientsWithPSPMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58