SR2640-hydrochloride-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemESR2640hydrochlorideCat.No.:HY-107610CASNo.:146662-42-2分?式:C??H??ClN?O?分?量:406.86作?靶點(diǎn):LeukotrieneReceptor作?通路:GPCR/GProtein儲(chǔ)存?式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:250mg/mL(614.46mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.4578mL12.2892mL24.5785mL5mM0.4916mL2.4578mL4.9157mL10mM0.2458mL1.2289mL2.4578mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.08mg/mL(5.11mM);Clearsolution2.請(qǐng)依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.08mg/mL(5.11mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性SR2640(hydrochloride)?種有效且具有選擇性與競(jìng)爭(zhēng)性的leukotrieneD4/leukotrieneE4拮抗劑。SR2640可?于研究?三烯在?類哮喘中的作?[1]。IC50&TargetLTD4andLTE4[1]體內(nèi)研究SR2640inhibitstheLTD4-inducedcontractionsofguinea-pigileuminaconcentration-dependentmanner,withanIC50of3nM[1].SR2640(1mg/kg;IV;singledosage)specificallypreventsthecontractileresponsesofguinea-pigileumandtracheatoLTD4andLTE4[1].AnimalModel:Guineapigs(injectedwithLTD4andLTE4)[1]Dosage:1mg/kgAdministration:IV;singledosageResult:Specificallypreventedthecontractileresponsesofguinea-pigileumandtracheatoLTD4andLTE4.REFERENCES[1].Ahnfelt-R?nneI,KirsteinD,Kaergaard-NielsenC.AnovelleukotrieneD4/E4antagonist,SR2640(2-[3-(2-quinolylmethoxy)phenylamino]benzoicacid).EurJPharmacol.1988;155(1-2):117-128.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:40