Coenzyme-Q9-Ubiquinone-Q9-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemECoenzymeQ9Cat.No.:HY-101415CASNo.:303-97-9Synonyms:UbiquinoneQ9;CoQ9;Ubiquinone9分?式:C??H??O?分?量:795.23作?靶點:Apoptosis;EndogenousMetabolite作?通路:Apoptosis;MetabolicEnzyme/Protease儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗Ethanol:12.5mg/mL(15.72mM;Needultrasonicandwarming)DMSO:2mg/mL(2.51mM;ultrasonicandwarmingandheatto80°C)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.2575mL6.2875mL12.5750mL5mM0.2515mL1.2575mL2.5150mL10mM0.1257mL0.6287mL1.2575mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。BIOLOGICALACTIVITY?物活性CoenzymeQ9(UbiquinoneQ9)嚙齒類動物泛醌的主形式，電?傳遞鏈中的?種雙親分?組分，具有內(nèi)性抗氧化劑的作?。CoenzymeQ9可減輕糖尿病引起的抗氧化防御機制的下降。CoenzymeQ9改左?室1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE功能，減少?肌梗死積和?肌細胞凋亡。IC50&TargetHumanEndogenousMetabolite體內(nèi)研究CoenzymeQ9(5mg/kg;p.o.;onceadayfor4weeks)reducesmyocardialischemia/reperfusioninjury[2].CoQ10andCoQ9arecomponentsofthemitochondrialrespiratorychaininmammalsandcanregulatesomemitochondrialproteins/functions.Soybean,corn,andrapeseedoilsareveryrichsourcesofCoQ10,whereasCoQ9hasbeenfoundinhighconcentrationsincornoil[3].ThelackofafunctionalCoQ9proteininhomozygousCoQ9mutant(CoQ9(X/X))micecausesaseverereductionintheCoQ7proteinandawidespreadCoQdeficiencyandaccumulationofdemethoxyubiquinone.ThedeficitinCoQinducesabrain-specificimpairmentofmitochondrialbioenergeticsperformance,areductioninrespiratorycontrolratio,ATPlevelsandATP/ADPratioandspecificlossofrespiratorycomplexI.TheseeffectsleadtoneuronaldeathanddemyelinizationwithseverevacuolizationandastrogliosisinthebrainofCoQ9(X/X)micethatconsequentlydiebetween3and6monthsofage[4].AnimalModel:MaleHartleyguineapigsofabout350-400gbodyweight[2]Dosage:5mg/kgofbodyweightAdministration:P.o.;onceadayfor4weeksResult:NutritionalsupplementationofCoQ9canreducemyocardialischemia/reperfusioninjurytothesameextentasCoQ10.REFERENCES[1].LekliI,etal.CoenzymeQ9providescardioprotectionafterconvertingintocoenzymeQ10.JAgricFoodChem.2008Jul9;56(13):5331-7.[2].VenegasC,etal.DeterminationofcoenzymeQ10,coenzymeQ9,andmelatonincontentsinvirginarganoils:comparisonwithotherediblevegetableoils.JAgricFoodChem.2011Nov23;59(22):12102-8.[3].García-CorzoL,etal.DysfunctionalCoq9proteincausespredominantencephalomyopathyassociatedwithCoQdeficiency.HumMolGenet.2013Mar15;22(6):1233-48.[4].WoldLE,etal.Insulin-likegrowthfactorI(IGF-1)supplementationpreventsdiabetes-inducedalterationsincoenzymesQ9andQ10.ActaDiabetol.2003;40(2):85-90.McePdfHeightCaution:Producthasnotbeenfullyvalidatedform