AOC第一章有機(jī)反應(yīng)基本原理

AdvancedOrganicChemistryZhulili1985年，出生于湖北天門2004-2008年，西南大學(xué)化學(xué)化工學(xué)院2008-2013年，中國人民大學(xué)化學(xué)系2013至今，周口師范學(xué)院講師。SelfIntroductionResearchInterest：OrganicSynthesis&OrganicReactionMethodology（1）金催化的一些新合成方法學(xué)的研究。（2）區(qū)域選擇性N2烷基三唑的合成方法學(xué)研究。

電話有機(jī)化學(xué)有用有機(jī)合成物理有機(jī)有機(jī)分析合成一個新世界有機(jī)化學(xué)該怎么學(xué)？？？學(xué)習(xí)有機(jī)化學(xué)的難點(diǎn)：多，雜，規(guī)律性差是不是這個原因讓人望而生畏，不全是!!!!!!有哪一種科學(xué)比記GRE單詞更多，更雜，更沒有規(guī)律性？？文獻(xiàn)：<<Science>>,<<Nature>>與有機(jī)化學(xué)有關(guān)的一些期刊ACS系列:JournalofAmericanChemicalSocietyJournalofOrganicChemistryOrganicLettersOrganometallicsWieley系列:AngewChemieInternationaleditionChemistry,AEuropeanJournalChemistry,AAsianJournalEuropeanJournaloforganicChemistry

Rsc系列：ChemicalScience,ChemicalCommunicationElsevier系列：TetrahedronTetrahedronLettersTetrahedronAsymmetry檢索工具：ScienceFinderBeilsteinCrossfireWebofScience有機(jī)化學(xué)的研究方法，學(xué)習(xí)方法

chemistry學(xué)習(xí)方法：youshouldremembersthinorganicchemistry,justlikestudyingalanguage.Howtolearn<<AdvancedOrganicChemistry>>.Thebasicrequirment:trytounderstandeachfigure,andtellyourselfwhatisgoingon.RememberBasicReactionsandtheirmechanismThereareseveralgeneralreactiontypesinorganictransformation,suchas:radicalreaction,polarreaction,andmetalcatalyzedreaction.

Therearesomeuniversaleffectsgoverningchemicalreactions,suchas:stericeffect,electroniceffect,etc.Trytoexplainthereactionphenomenonusingdifferentreactiontypesanddifferentreactionfactors.Trytopredictsomenewreaction,andthenverifyorfalsifyitthroughexperiments.

AccomplishmentsoforganicsynthesisinthetwentiethcenturyR.B.Woodward1917-1979介紹一些有機(jī)合成化學(xué)的大師1965NobelPrizeWinner.“forhisoutstandingachievementsintheartoforganicsynthesis.”SelectedsynthesesbytheWoodwardGroup(1944-1981).Ref:Angew.Chem.Int.Ed.2000,39,44–122.…Coreyhasthusbeenawardedwiththe1990nobelPrizeforthreeintimatelyconnectedcontributions,whichformawhole.Throughretrosyntheticanalysisandintroductionofnewsyntheticreactions,hehassucceededinpreparingbiologicallyimportantnaturalproducts,previouslythoughtimpossibletoachieve.Corey’scontributionshaveturnedtheartofsynthesisintoascience…NobelLectures:Chemistry1981-1990,WorldScientific,NewJersey,1992,pp677-708.E.G.Corey1928-TheNobelPrizeinChemistry2001ThesuccessofasymmetrichydrogenationlargelyusingBINAP-Rucomplexandits’extensiveusefulnessinindustry.RyojiNoyori1938-介紹一些有機(jī)合成方法學(xué)的大師TheNobelPrizeinChemistry2001

Thesuccessofasymmetricepoxidationandasymmetricdihydroxyaltionofthealkene.K.BarrySharpless1941-TheNobelPrizeinChemistry2005goestoYvesChauvin,RobertH.GrubbsandRichardR.Schrock"forthedevelopmentofthemetathesismethodinorganicsynthesis".OlefinMetathesis/GrubbsReaction:OlefinMetathesisallowstheexchangeofsubstituentsbetweendifferentolefins-atransalkylidenation.

CouplingReactionTheRoyalAcademyofSciencesannouncestheNobelPrizeinChemistry2010awardedjointlyto(portraitsseenonscreenfromleft)USA'sRichardF.Heck,JapaneseEi-ichiNegishiandAkiraSuzukiinStockholmonOctober6,2010.RichardHeckoftheUnitedStatesandJapan'sEi-ichiNegishiandAkiraSuzukisharedthe2010NobelChemistryPrizeWednesdayforpioneeringresearchinlinkingcarbonatoms.TheRoyalSwedishAcademyofScienceslaudedthetrio'sworkin"thedevelopmentofpalladium-catalyzedcrosscoupling."我所希望的教學(xué)模式課堂的教學(xué)學(xué)生課后的反饋Referencebook：《AdvancedOrganicChemistry》PartA:StrutureandMechanismsPartB:ReactionsandSynthesis

FrancisA.Carey&RichardJ.Sundberg高等有機(jī)化學(xué)-------反應(yīng)與機(jī)理BernardMiller吳范宏譯華東理工大學(xué)出版社現(xiàn)代有機(jī)反應(yīng)(五卷)

胡躍飛林國強(qiáng)主編化學(xué)工業(yè)出版社1，有機(jī)反應(yīng)的基本原理（2）2，取代基效應(yīng)（5）3，取代、加成反應(yīng)（8,9,11,12）4，消去反應(yīng)（10）5，氧化還原反應(yīng)（13）6，重排反應(yīng)（15）7，周環(huán)反應(yīng)（16）考核辦法：平時成績（10%）+作業(yè)（20%）+期末成績（70%）Tellmewhathappenedifyouarenotavailable!!Makeagoodhomework!Thisisdefinitelyyouredge！第二章有機(jī)反應(yīng)的基本原理一、反應(yīng)的分類（1）按反應(yīng)歷程自由基反應(yīng)：通過共價鍵的均裂而進(jìn)行的反應(yīng)。自由基反應(yīng)一般在光或熱的作用下進(jìn)行。離子型反應(yīng)：通過共價鍵的異裂而進(jìn)行的反應(yīng)。離子型反應(yīng)一般在酸、堿等極性試劑的作用下進(jìn)行。它又分為親核反應(yīng)和親電反應(yīng)。協(xié)同反應(yīng)：舊鍵的斷裂和新鍵的生成是同時進(jìn)行的。（2）按原料和產(chǎn)物取代反應(yīng)：鹵代