Risdiplam-RG7916-DataSheet-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemERisdiplamCat.No.:HY-109101CASNo.:1825352-65-5Synonyms:RG7916;RO7034067分?式:C??H??N?O分?量:401.46作?靶點:DNA/RNASynthesis作?通路:CellCycle/DNADamage儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據體外實驗Ethanol:<1mg/mL(insoluble)DMSO:1.7mg/mL(4.23mM;ultrasonicandwarmingandheatto60°C)H2O:<0.1mg/mL(insoluble)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.4909mL12.4545mL24.9091mL5mM---------10mM---------請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內使?，-20°C儲存時，請在1個?內使?。BIOLOGICALACTIVITY?物活性Risdiplam(RG7916)?種運動神經元存活因SMN2的前體mRNA剪接修飾劑，可增加SMN蛋??平1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE[1]。IC50&TargetSMN2體外研究RisdiplammodulatesSMN2pre-mRNAsplicingtowardstheproductionoffull-lengthSMN2mRNAandincreasesSMNproteinlevels.RisdiplamisamodifierofSMN2splicing,leadingtoanincreaseinSMN2fulllengthtranscriptandthusfunctionalSMNprotein.Spinalmuscularatrophy(SMA)typeIremainsthemostcommongeneticdiseaseresultingindeathininfancy.Characterizedbyprogressivemotorandrespiratorymuscleweakness,thisautosomalrecessiveneuromusculardisorderiscausedbylowlevelsofthesurvivalmotorneuronprotein(SMN)duetoinactivatingbi-allelicdeletionsandotherdisablingmutationsinthesurvivalmotorneuron1(SMN1)gene[1].戶使?本產品發(fā)表的科研?獻?NucleicAcidsRes.2021Sep7;49(15):8462-8470.?CellMolLifeSci.2022Jul22;79(8):441.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].PoirierA,etal.RisdiplamdistributesandincreasesSMNproteininboththecentralnervoussystemandperipheralorgans.PharmacolResPerspect.2018Nov29;6(6):e00447.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820