2023年分析化學考研面試問題

藥物分析實驗典型問題鑒別檢查在藥品質(zhì)量控制中的意義及一般雜質(zhì)檢查的重要項目是什么?Whatarethepurposesofdrugidentificationandtest?Whataretheusualitemsofdrugtests?.比色比濁操作應遵循的原則是什么?Whatarethestandardoperationproceduresfortheclaritytest?試計算葡萄糖重金屬檢查中標準鉛溶液的取用量。Howmuchoftheleadstandardsolutionshouldbetakenforthelimittestforheavymetalsinthisexperiment?古蔡氏試砷法中所加各試劑的作用與操作注意點是什么?Whatprecautionsshouldbetakenforthelimittestforarsenic(AppendixVIIIJ，method1)?Andwhatisthefunctionforeachofthetestsolutionsadded?根據(jù)樣品取用量、雜質(zhì)限量及標準砷溶液的濃度，計算標準砷溶液的取用量。Figureouttheamountofthearsenicstandardsolutionthatshouldbetakenforthelimittestforarsenic(AppendixVIIIJ，method1)(0.0001%)inthisexperimentwiththespecifiedquantityof2.0gofsample.熾灼殘渣測定的成敗關鍵是什么？什么是恒重？Whatisthekeystepduringthedeterminationofresidueonignition?Whatdoes‘igniteordrytoconstantweight’mean?鹽酸普魯卡因的鑒別原理是什么？WhataretheprinciplesoftheidentificationofProcaineHydrochloride.鹽酸普魯卡因注射液中為什么要檢核對氨基苯甲酸？Whyisthelimitof4-aminobenzoicacidtestedforProcaineHydrochloride?薄層色譜法檢查藥物中有關物質(zhì)的方法通常有哪幾種類型?本實驗屬于哪種?與其它方法有何異同點?Howmanykindsofthelimittestsforrelatedcompoundsarethere?Whatarethedifferencesbetweenthem?Whichoneisusedforthelimittestof4-amino-benzoicacidinProcaineHydrochlorideInjection?醋酸氫化可的松的鑒別原理是什么？Whataretheprinciplesoftheidentificationofhydrocortisoneacetate?甾體激素中“其它甾體”檢查的意義和常用方法是什么？Whatarethecommonlyusedmethodforandthesignificanceofthelimittestforothersteroidsforthesteroidaldrugs?哪類甾體激素可與四氮唑藍產(chǎn)生反映，是結(jié)構中的何種基團參與了反映，反映式是什么？WhatkindofsteroidaldrugscanreactwiththealkalinetetrazoliumblueTS?Whatisthechemicalreactionequation?氯貝丁酯的鑒別原理是什么？Whataretheprinciplesoftheidentificationofclofibrate?氯貝丁酯中為什么要檢核對氯酚？其方法及原理是什么？Whyisthelimitofp-Chlorophenoltestedforclofibrate?Whatkindofmethodisemployedforthetestandwhatistheprinciple?氣相色譜法檢查雜質(zhì)有哪些方法，試比較各種方法的特點？Howmanytypesofmethodsarethereforthetestofrelatedcompoundsbythegaschromatography?Whatarethedifferencesbetweenthem?抗生素類藥物的鑒別和檢查有何特點？Whatarethecharacteristicsfortheidentificationandtestsofantibiotics?鈉鹽的焰色反映應注意什么？Whatprecautionsshouldbetakenduringtheflamereactionofsodiumsalts?本品吸取度檢查的意義是什么？Whatisthepurposeofthelightabsorptiontestsforbenzylpenicillinsodium?藥物晶型測定的常用方法有哪些，各有什么特點？Whatarethecommonlyusedmethodsforthetestofpolymorphism?Andwhatarethecharacteristicsofeachofthem?吸取系數(shù)測定方法與規(guī)定？Whatarethestandardoperationproceduresfortheestablishmentofspecificabsorbance?寫出異煙肼與溴酸鉀的滴定反映式和滴定度的計算過程。Whatarethechemicalreactionequationsandtheequivalentrelationshipfortheassayofisoniazidbythemethodofpotassiumbromate(0.01667mol/L)VStitration.當游離肼不合格時，對測定有何影響？Ifthetestforthefreehydrazinedoesnotcomply，whatwillhappentotheresultsoftheassayofisoniazidbythepotassiumbromatetitration?葡萄糖旋光度法測定含量時，為什么要加氨試液并放置后進行測定？WhyshouldtheammoniaTSbeaddedtothesolutionwhichisthenallowedtostandfor10minutesintheassayofglucosebythemethodofopticalrotation?推算出旋光度法測定葡萄糖含量時的計算系數(shù)2.0852；Figureoutthecoefficientof2.0852inthecalculationoftheglucosecontentintheassayofglucosebythemethodofopticalrotation.寫出剩余碘量法測定葡萄糖化學反映過程。Figureoutthechemicalreactionequationsandtheequivalentrelationshipfortheassayofglucosebythemethodofiodinetitration.哪些巴比妥藥物能用銀量法進行含量測定？為什么？Whatkindofbarbitalscanbeassayedbythepotentiometrictitrationwithsilvernitrate?水溶液銀量法電位滴定中采用的電極系統(tǒng)是什么？Whattypeofelectrodepairsshouldbeusedforthepotentiometrictitrationwithsilvernitrate?寫出高氯酸滴定硫酸奎尼丁的滴定反映式并計算滴定度？FigureoutthechemicalreactionequationofQuinidineSulfatewithperchloricacidandtheequivalentrelationship.非水滴定法中常見酸根的影響如何消除？Howtocircumventtheinterferencesofotheracidduringthenon-aqueoustitrationofbasicdrugswithperchloricacid?非水滴定的注意事項有哪些？常用終點指示方法是什么？Whatprecautionsshouldbetakenduringthenon-aqueoustitration?Whatarethecommonlyusedmethodsfortheend-pointindicatingduringthetitration?寫出亞硝酸鈉滴定鹽酸普魯卡因的滴定反映式并計算滴定度？FigureoutthechemicalreactionequationofProcaineHydrochloridewithsodiumnitriteandtheequivalentrelationship.亞硝酸鈉滴定的合用范圍是什么？注意事項有哪些？常用終點指示方法有哪些？Whattypeofcompoundsmaybeassayedwiththedead-stoptitrationbysodiumnitrite?Whatprecautionsshouldbetakeninthedead-stoptitration?Whatotherend-pointindicatingmethodsarethere?氧瓶燃燒操作的注意事項有哪些？Whatprecautionsshouldbetakentoconducttheoxygenflaskcombustionmethod?如何選擇氧瓶燃燒法的吸取溶液？Howtoselecttheabsorbingliquidfortheoxygenflaskcombustionmethod?氧瓶燃燒法在藥物分析中的重要應用有哪些？Whatarethemajorapplicationsoftheoxygenflaskcombustionmethodintheanalysisofdrugs?為什么供肌內(nèi)注射用肌甘注射液含量測定期必須先進行紙色譜分離？Whyisthepaperchromatographicseparationusedfortheassayofintramascularinjectionofinosine?本測定法平行實驗相對誤差的限度應當小于多少？Whatistherequirementoftheprecisionoftheassayofinosineforintramascularinjection?各國藥典中維生素A的含量測定為什么都采用分光光度方法？WhyarethespectrophotometricassaymethodusedfortheassayofVitaminAinallthepharmacopoeias?試推導出各種不同情況下維生素A含量測定的計算式。FigureoutalltheequationsforthecalculationofthecontentofVitaminA氣相色譜測定維生素E含量時為什么使用內(nèi)標法？WhyistheinternalreferencestandardmethodemployedfortheassayofVitaminEbyGC?試述氣相色譜法的特點及分析合用范圍。GiveanexplanationofthefeaturesandapplicationsofGCmethod?維生素E含量測定的其它方法有哪些？各有什么特點？WhatothermethodsaretherefortheassayofVitaminE?阿司匹林原料藥物與及阿司匹林腸溶片在質(zhì)量檢查方面有哪些不同之處？為什么不同？Whatisthedifferencebetweentheassayofaspirinanditsenteric-coatedtablets?阿司匹林腸溶片釋放度檢查中為什么要更換溶劑？Giveanexplanationofthepurposeofthesolventchangingduringthedrugreleasetestofaspirinenteric-coatedtablets.氫溴酸東莨菪堿的鑒別原理是什么？Whatarethechemicalreactioncharacteristicsoftropanealkaloids?氫溴酸東莨菪堿片含量測定的方法與原理是什么？Whatkindofmethodisemployedfortheassayofscopolaminehydrobromidetablets?氫溴酸東莨菪堿片含量均勻度檢查的意義是什么？Whyisthecontentuniformitytestedforthescopolaminehydrobromidetablets?本品中甲苯咪唑的含量為什么可以用分光光度法測定？Whycanthecontentofmebendazoleofthiscompoundtabletbeassayedbythespectrophotometricmethod?本品中鹽酸左旋咪唑含量測定期，為什么甲苯咪唑沒有干擾？Whydoesmebendazolenotinterferewiththetitrationoflevamisolehydrochlorideinchloroform?分別說明本品中磺胺甲噁唑和甲氧芐啶雙波長法含量測定期波長選擇的依據(jù)；Giveanexplanationofthebasisofthewavelengthselectionforthedeterminationofsulfamethoxazoleandtrimethoprim，respectively.為什么甲氧芐啶含量測定期供試液的稀釋倍數(shù)與磺胺甲噁唑測定期的要不同？Whyisthemoredilutedsolutionusedfortheassayoftrimethoprimthanthatforsulfamethoxazole?本品HPLC法檢查色譜系統(tǒng)合用性實驗有什么意義？WhatisthesystemsuitabilitytestoftheHPLCmethod?GiveanexplanationoftheimportanceofthesystemsuitabilitytestoftheHPLCmethodduringtheassayandthetestofrelatedsubstances.藥品含量以干燥品計算或無水物計算有何不同？Whatisthedifferencebetweenthecontentsofdrugswhenitiscalculatedontheanhydrousbasisandonthedriedbasis?寫出鹽酸克侖特中2，4-二硝基苯肼鑒定的化學反映式。Whatarethecompletechemicalprocessesoftheidentificationofclenbuterolhydrochlorideby2,4-dinitrophenylhydrazine.鹽酸克侖特中總氯量測定的滴定方法是什么？滴定過程中加硝基苯并強力振搖的目的是什么？Whatkindoftitrationmethodisemployedforthetotalchloridetestforclenbuterolhydrochloride?Whatisthepurposeoftheadditionof3mlofnitrobenzeneandshakingvigorously?鹽酸克侖特含量測定采用的永停滴定法的原理是什么？有哪些注意事項？Whatistheprincipleofpotentio-metrictitrationfortheassayofclenbuterolhydrochloride?Whatprecautionsshouldbetakenduringthetitration?試述抗生素藥物有關物質(zhì)檢查的意義？Whatistheimportanceofthetestofrelatedsubstancesforantibiotics.頭孢克洛水分測定的意義？Whatisthepurposeforthetestandcontrolofwatercontentforantibiotics?抗生素藥物含量或效價測定的方法有哪些？各有什么特點？Whatothermethodsaretherefortheassayofantibiotics?Giveanexplanationofthecharacteristicsofeachmethod.槐花的重要化學成分有哪些？WhatkindofchemicalsarethereintheFlosSophorae?藥材浸出測定方法中，冷浸法與熱浸法各有什么特點？水浸出物與醇浸出物有什么區(qū)別？Whatisthedifferencebetweenthehotandcoldextractionmethodsasdescribedunderthedeterminationofextractives？Whatisthedifferencebetweentheethanol-solubleandwater-solubleextractives？槐花與鎂粉-鹽酸反映鑒別的化合物的類別是什么？反映原理是什么？Whatkindofcompoundsareidentifiedbythecolorreactionwithasmallquantityofmagnesiumpowderand2~3dropsofhydrochloricacid？Whatarethereactionprocesses？槐花比色法含量測定的原理是什么？先加乙醚加熱回流提取的目的是什么？Whatistheprincipleofthephotometricassayofthisdrug？WhatisthepurposeoftheSoxhiet'sextractionwithether？石菖蒲的重要化學成分有哪些？WhatkindsofcomponentsarethereinthevolatileoilobtainedundertheAssay?石菖蒲揮發(fā)油用甲法進行測定；若用乙法測定須加入二甲苯1.0ml，其目的是什么？Thefirstmethodforthedeterminationofvolatileoilisemployedfortheassay.Whatisthepurposefortheadditionof1.0mlofxyleneifthesecondmethodwasemployed?供揮發(fā)油測定用的供試品，須粉碎使能通過二號至三號篩，為什么？Whatshouldbedonetothedrugbeforethedeterminationofvolatileoil?中成藥含量測定及鑒別實驗中檢測對象的選擇原則有哪些？本品為什么選擇丹皮酚和熊果酸進行含量測定？Whyarepaeonolandursolicacidselectedfortheassayofthisdrug?WhatistheprinciplefortheassayandidentificationoftraditionalChinesemateriamedica?熊果酸含量薄層掃描法測定期，用10%硫酸乙醇噴霧顯色后，薄層板上為什么要覆蓋同樣大小的玻璃板？Whyshouldtheplatebecoveredwithaglassplateofthesamesizeandfixedupwithadhesiveplasterintheassayofursolicacid,aftersprayingwith10%solutionofsulfuricacidinethanolandheatingat105℃在中成藥及中藥材的薄層色譜鑒別中何時采用對照藥材法？Whensh