抑郁癥的動物模型

Iamdepressed.

Metoo.第1頁/共19頁第一頁，共20頁。Whyweneedanimalmodels?Thesortsofanimalmodels.Thefuturedevelopmentofanimalmodels.第2頁/共19頁第二頁，共20頁。Theusesofanimalmodels

Antidepressantsscreening.

Mechanismstudying第3頁/共19頁第三頁，共20頁。神經生化功能改變模型應激模型條件性飼養(yǎng)模型基因工程動物模型第4頁/共19頁第四頁，共20頁。獲得性無助模型

(learnedhelpless)慢性溫和應激模型

(chronicmildstress)行為絕望模型

(behavioraldespair)第5頁/共19頁第五頁，共20頁。Gene-engineeringmiceConventionaltransgenicmiceConditionalgene-targetingmethodsAntisensetargeting第6頁/共19頁第六頁，共20頁。第7頁/共19頁第七頁，共20頁。第8頁/共19頁第八頁，共20頁。第9頁/共19頁第九頁，共20頁。第10頁/共19頁第十頁，共20頁。5-HT1A受體敲除抗抑郁表型糖皮質激素受體基因損傷抗抑郁表型，焦慮相關的行為減少(有待進一步確定)5-HT1B受體敲除拮抗抗抑郁表型，對SSRI類抗抑郁藥敏感性增加谷氨酸脫羧酶基因敲除抗抑郁表型DA-β-羥化酶基因敲除拮抗抗抑郁表型神經細胞黏附分子基因敲除抗抑郁表型α2A-腎上腺素能受體基因敲除抑郁表型，并拮抗抗抑郁表型TNFα基因敲除抗抑郁表型α2C-腎上腺素能受體基因敲除抗抑郁表型血管緊張素基因敲除抗抑郁表型α2C-腎上腺素能受體基因過表達抑郁表型腺苷受體基因敲除抗抑郁表型NE轉運子基因敲除抗抑郁表型速激肽NK1受體基因敲除抗抑郁表型單胺氧化酶A基因敲除抗抑郁表型IL-6基因敲除拮抗抗抑郁表型單胺氧化酶B基因敲除抗抑郁表型多巴胺D5受體基因敲除抗抑郁表型μ阿片受體基因敲除抗抑郁表型DARPP基因敲除對鹽酸氟西汀敏感性降低δ阿片受體基因敲除抑郁表型CREB突變抗抑郁表型Gα-G-蛋白敲除拮抗抗抑郁表型BDNF條件性基因敲除抗抑郁表型，對電擊敏感性降低5-HT1A受體敲除抗抑郁表型TrkB基因敲除抗抑郁表型，對抗抑郁藥敏感性降低第11頁/共19頁第十一頁，共20頁。展望

實驗動物模型是研究抑郁癥必不可少的工具。隨著基因工程技術的出現(xiàn)，實驗模型的可操作性和多樣性都大大改善了。雖然轉基因技術仍存在很多問題，但其仍有著光明的前景。第12頁/共19頁第十二頁，共20頁。

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