抑郁癥的動(dòng)物模型

Iamdepressed.

Metoo.第1頁(yè)/共19頁(yè)第一頁(yè)，共20頁(yè)。Whyweneedanimalmodels?Thesortsofanimalmodels.Thefuturedevelopmentofanimalmodels.第2頁(yè)/共19頁(yè)第二頁(yè)，共20頁(yè)。Theusesofanimalmodels

Antidepressantsscreening.

Mechanismstudying第3頁(yè)/共19頁(yè)第三頁(yè)，共20頁(yè)。神經(jīng)生化功能改變模型應(yīng)激模型條件性飼養(yǎng)模型基因工程動(dòng)物模型第4頁(yè)/共19頁(yè)第四頁(yè)，共20頁(yè)。獲得性無(wú)助模型

(learnedhelpless)慢性溫和應(yīng)激模型

(chronicmildstress)行為絕望模型

(behavioraldespair)第5頁(yè)/共19頁(yè)第五頁(yè)，共20頁(yè)。Gene-engineeringmiceConventionaltransgenicmiceConditionalgene-targetingmethodsAntisensetargeting第6頁(yè)/共19頁(yè)第六頁(yè)，共20頁(yè)。第7頁(yè)/共19頁(yè)第七頁(yè)，共20頁(yè)。第8頁(yè)/共19頁(yè)第八頁(yè)，共20頁(yè)。第9頁(yè)/共19頁(yè)第九頁(yè)，共20頁(yè)。第10頁(yè)/共19頁(yè)第十頁(yè)，共20頁(yè)。5-HT1A受體敲除抗抑郁表型糖皮質(zhì)激素受體基因損傷抗抑郁表型，焦慮相關(guān)的行為減少(有待進(jìn)一步確定)5-HT1B受體敲除拮抗抗抑郁表型，對(duì)SSRI類抗抑郁藥敏感性增加谷氨酸脫羧酶基因敲除抗抑郁表型DA-β-羥化酶基因敲除拮抗抗抑郁表型神經(jīng)細(xì)胞黏附分子基因敲除抗抑郁表型α2A-腎上腺素能受體基因敲除抑郁表型，并拮抗抗抑郁表型TNFα基因敲除抗抑郁表型α2C-腎上腺素能受體基因敲除抗抑郁表型血管緊張素基因敲除抗抑郁表型α2C-腎上腺素能受體基因過表達(dá)抑郁表型腺苷受體基因敲除抗抑郁表型NE轉(zhuǎn)運(yùn)子基因敲除抗抑郁表型速激肽NK1受體基因敲除抗抑郁表型單胺氧化酶A基因敲除抗抑郁表型IL-6基因敲除拮抗抗抑郁表型單胺氧化酶B基因敲除抗抑郁表型多巴胺D5受體基因敲除抗抑郁表型μ阿片受體基因敲除抗抑郁表型DARPP基因敲除對(duì)鹽酸氟西汀敏感性降低δ阿片受體基因敲除抑郁表型CREB突變抗抑郁表型Gα-G-蛋白敲除拮抗抗抑郁表型BDNF條件性基因敲除抗抑郁表型，對(duì)電擊敏感性降低5-HT1A受體敲除抗抑郁表型TrkB基因敲除抗抑郁表型，對(duì)抗抑郁藥敏感性降低第11頁(yè)/共19頁(yè)第十一頁(yè)，共20頁(yè)。展望

實(shí)驗(yàn)動(dòng)物模型是研究抑郁癥必不可少的工具。隨著基因工程技術(shù)的出現(xiàn)，實(shí)驗(yàn)?zāi)Ｐ偷目刹僮餍院投鄻有远即蟠蟾纳屏恕ｋm然轉(zhuǎn)基因技術(shù)仍存在很多問題，但其仍有著光明的前景。第12頁(yè)/共19頁(yè)第十二頁(yè)，共20頁(yè)。

Reference___________________________________________________________________________________________1．JanneGr?nlia,.,RobertMurisonb,d,Bj?rnBjorvatnc,d,EliS?rensena,ChiaraM.Portasa,ReidunUrsina,d，Chronicmildstressaffectssucroseintakeandsleepinrats，BehaviouralBrainResearch150(2004)139–1472．JohnF.Cryan,DanielHoyer,andAthinaMarkou，WithdrawalfromChronicAmphetamineInducesDepressive-LikeBehavioralEffectsinRodents，BIOLPSYCHIATRY2003;54:49–583．AndrewHarkin*,JohnP.Kelly,BrianE.Leonard，Areviewoftherelevanceandvalidityofolfactorybulbectomyasamodelofdepression，ClinicalNeuroscienceResearch3(2003)253–2624.VijayakumarMavanjia,b,SubimalDattaa,*，Clomipraminetreatmentinneonatalratsaltersthebrainacetylcholinesteraseactivityinadulthood，NeuroscienceLetters330(2002)119–1215.RuthE.Grahna,*,S.E.Hammacka,M.J.Willb,K.A.O’Connora,T.Deakc,P.D.Sparksa,L.R.Watkinsa,S.F.Maiera,Blockadeofalpha1adrenoreceptorsinthedorsalraphenucleuspreventsenhancedconditionedfearandimpairedescapeperformancefollowinguncontrollablestressorexposureinrats,BehaviouralBrainResearch134(2002)387_/3926.PeterGassa,*,HolgerM.Reichardtb,TatyanaStrekalovaa,FritzHenna,FrancoisTroncheb,Micewithtargetedmutationsofglucocorticoidandmineralocorticoidreceptors:Modelsfordepressionandanxiety?Physiology&Behavior73(2001)811–8257.AlexandreUrani,SabineChourbaji,FritzA.Henn,PeterGass*，Modelingdepressionwithtransgenicmice:theneurotrophinhypothesisrevisited，ClinicalNeuroscienceResearch3(2003)263–2698．MarianneB.Mu¨ller*,MartinE.Keck，Geneticallyengineeredmiceforstudiesofstress-relatedclinicalconditions，JournalofPsychiatricResearch36(2002)53–769．EricJ.Nestler,ElizabethGould,HusseiniManji,MajaBucan,RonaldS.Duman,HowardK.Gershenfeld,ReneHen,SusanKoester,IsraelLederhendler,MichaelJ.Meaney,TrevorRobbins,LoisWinsky,andSteveZalcman,PreclinicalModels:StatusofBasicResearchinDepression,BIOLPSYCHIATRY2002;52:503–528第13頁(yè)/共19頁(yè)第十三頁(yè)，共20頁(yè)。10．OvermierJB,SeligmanME.Effectsofinescapableshockuponsubsequentescapeandavoidanceresponding.JCompPhysiolPsychol1967;63:28–33.neurotransmitterreleaseinananimalmodelofdepression.NeurochemInt1992;21:29–35.11．BarbaraVollmayr*,FritzA.Henn，Stressmodelsofdepression，ClinicalNeuroscienceResearch3(2003)245–25112．KatzRJ,SchmaltzK.Dopaminergicinvolvementinattention.Anovelanimalmodel.ProgNeuropsychopharmacol1980;4:585–90.Psychopharmacology13．WillnerP,TowellA,SampsonD,SophokleousS,MuscatR.Reductionofsucrosepreferencebychronicunpredictablemildstressanditsrestorationbyatricyclicantidepressant.Psychopharmacology(Berl)1987;93:358–64.14．WillnerP,MuscatR,PappM.Chronicmildstress-inducedanhedonia:arealisticanimalmodelofdepression.NeurosciBiobehavRev1992;16:525–34.15．許晶

,李曉秋，慢性應(yīng)激抑郁模型的建立及其評(píng)價(jià)，

ChineseJournalofBehavioralMedicalScience12(1),200316.MoreauJL,ScherschlichtR,JenckF,MartinJR.Chronicmildstressinducedanhedoniamodelofdepression;sleepabnormalitiesandcurativeeffectsofelectroshocktreatment.BehavPharmacol1995;6:682–7.17．呂俊華,鐘玲，實(shí)驗(yàn)性抑郁癥動(dòng)物模型的評(píng)價(jià)，中國(guó)病理生理雜志ChineseJournalofPathophysiology

2001,17(9):916-91918.JohnF.Cryan,AthinaMarkouandIrwinLucki，Assessingantidepressantactivityinrodents:recentdevelopmentsandfutureneedsTRENDSinPharmacologicalSciencesVol.23No.5May200219.郭建友，李昌煜，葛衛(wèi)紅,抑郁癥動(dòng)物模型研究進(jìn)展,中國(guó)臨床康復(fù)第第八卷第10期第14頁(yè)/共19頁(yè)第十四頁(yè)，共20頁(yè)。感謝：肖遠(yuǎn)、陳怡、劉婷婷、王穎、李逸、閻焰、平星杰（排名不分先后