HDAC6-IN-14-DataSheet-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEHDAC6-IN-14Cat.No.:HY-151896分?式:C??H??FN?O?分?量:443.51作?靶點(diǎn):HDAC作?通路:CellCycle/DNADamage;Epigenetics儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性HDAC6-IN-14?種?選擇性HDAC6(HDAC)抑制劑，IC50為42nM。HDAC6-IN-14的選擇性是HDAC1/HDAC2/HDAC3/HDAC4的100倍以上。IC50&TargetHDAC6HDAC1HDAC2HDAC342nM(IC50)8.01μM(IC50)4.48μM(IC50)8.35μM(IC50)HDAC4>10μM(IC50)體外研究HDAC6-IN-14(compound10p;1-5μM;48h)treatmentresultsinasignificantapoptosisinductioninHL60cells[1].HDAC6-IN-14(compound10p;6-36μM;24h)treatmentinducesacetylationofα-tubulinbuthasnoeffectonAc-H3levelsevenatconcentrationsof≤36μMinHL60cells[1].ApoptosisAnalysis[1]CellLine:HL60cellsConcentration:1μMand5μMIncubationTime:48hResult:Resultedinasignificantapoptosisinduction.WesternBlotAnalysis[1]1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemECellLine:HL60cellsConcentration:6μM,12μM,24μM,36μMIncubationTime:24hResult:Inducedacetylationofα-tubulinbuthadnoeffectonAc-H3levels.REFERENCES[1].NinaRe?ing,etal.DevelopmentofFluorinatedPeptoid-BasedHistoneDeacetylase(HDAC)InhibitorsforTherapy-ResistantAcuteLeukemia.JMedChem.2022Nov24;65(22):15457-15472.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: