YPC-22026-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEYPC-22026Cat.No.:HY-120264CASNo.:1964457-41-7分?式:C??H?F?N?O?分?量:331.25作?靶點:Others作?通路:Others儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性YPC-22026?種鋅指蛋?143(ZNF143)抑制劑，IC50值為9.0μM。YPC-22026?種有效的腫瘤消退誘導(dǎo)劑。YPC-22026表現(xiàn)出抗腫瘤活性。體外研究YPC‐22026(96h)showscytotoxictoHCT116andPC‐3withIC50valuesof0.33μMand0.66μM,respectively[1].YPC‐22026(3μM;24h)inducesG2/MarrestanddecreasesthebindingofZNF143totheSTAFbindingsite[1].CellCycleAnalysis[1]CellLine:HCT116cellsConcentration:3μMIncubationTime:24hResult:InducedG2/Marrest.體內(nèi)研究YPC‐22026(50-100mg/kg;i.p;ondays1,2,3,8,9,12,and16)significantlyinhibitsthegrowthoftumorsintheHCT116xenograftmodel[1].InthePC‐3xenograftmodel,YPC‐22026(75mg/kg;ip)significantlydecreasesintheintratumoralexpressionlevelsofallZNF143targetgenes,RAD51,PLK1,andSurvivin[1].AnimalModel:Six1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE‐week‐oldmaleBALB/cnudemiceinjectedwithHCT116cells[1]Dosage:50mg/kgand100mg/kgAdministration:i.p;ondays1,2,3,8,9,12,and16(50mg/kg);ondays1,2,3,12,and16(100mg/kg)Result:Significantlyinhibitedthegrowthoftumors.REFERENCES[1].HirotakaHaibara,etal.YPC-21661andYPC-22026,novelsmallmolecules,inhibitZNF143activityinvitroandinvivo.CancerSci.2017May;108(5):1042-1048.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955