Methacholine-chloride-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEMethacholinechloride(Standard)Cat.No.:HY-A0083RCASNo.:62-51-1分?式:C?H??ClNO?分?量:195.69作?靶點(diǎn):mAChR作?通路:GPCR/GProtein;NeuronalSignaling儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Methacholine(chloride)(Standard)Methacholine(chloride)的分析標(biāo)準(zhǔn)品。本產(chǎn)品?于研究及分析應(yīng)?。Methacholine(Acetyl-β-methylcholine)choride?種有效的毒蕈堿-3muscarinic-3(M3)激動劑。Methacholinechoride直接作?于平滑肌上的?酰膽堿受體，導(dǎo)致??管收縮和?道變窄。Methacholinechoride對識別??管?反應(yīng)性(BHR)顯?出?靈敏度。Methacholinechoride可?于測量?道?反應(yīng)性(AHR)，作為評估具有哮喘樣癥狀和正常靜息呼?流速的個體的診斷輔助[1][2][3][4]。REFERENCES[1].CohenJ,etal.RelationshipbetweenairwayresponsivenesstoneurokininAandmethacholineinasthma.PulmPharmacolTher.2005;18(3):171-176.[2].AndersonSD,etal.Comparisonofmannitolandmethacholinetopredictexercise-inducedbronchoconstrictionandaclinicaldiagnosisofasthma.RespirRes.2009;10(1):4.Published2009Jan23.[3].CockcroftDW.Methacholinechallengemethods.Chest.2008;134(4):678-680.[4].KabaraS,etal.Differentialeffectsofthiopentalonmethacholine-andserotonin-inducedbronchoconstrictionindogs.BrJAnaesth.2003Sep;91(3):379-84.[5].FolkertsG,etal.Bradykinincausesinhibitionofmethacholine-inducedbronchoconstrictioninvivoinmice.NaunynSchmiedebergsArchPharmacol.2001Jul;364(1):53-8.[6].VitorassoRL,etal.Methacholinedoseresponsecurveandacceptabilitycriteriaofrespiratorymechanicsmodeling.ExpLungRes.2020Feb-Mar;46(1-2):23-31.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589