Phenanthrene-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEPhenanthrene(Standard)Cat.No.:HY-B1727RCASNo.:85-01-8分子式:C??H??分子量:178.23作用靶點(diǎn):Apoptosis作用通路:Apoptosis儲(chǔ)存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Phenanthrene(Standard)是Phenanthrene的分析標(biāo)準(zhǔn)品。本產(chǎn)品用于研究及分析應(yīng)用。Phenanthrene是一種具有口服活性的多環(huán)芳烴(PAH)，可以誘導(dǎo)炎癥、氧化應(yīng)激以及細(xì)胞凋亡(Apoptosis)。此外，Phenanthrene常被用于檢測(cè)或評(píng)估環(huán)境中的PAH污染[1][2][3][4]。體外研究Phenanthrene(1-300μM,48h)significantlyreducesthemitochondrialmembranepotential(MMP)inprimaryhepatocytesoftheChineserareminnow(Gobiocyprisrarus)[4].體內(nèi)研究Phenanthrene(180and900mg/kg,p.o.,administeredonceonthefirstday;90and450mg/kg,i.p.,administeredonceadayonthenext2days)inducesoxidativestressandinflammationinWistarfemalerats[3].Phenanthrene(10-1000μg/mL,exposurefor30days)cancauseliverdamageandpromotehepatocyteapoptosisinChineserareminnows(Gobiocyprisrarus)[4].AnimalModel:Wistarfemalerats(180-200g)[3]Dosage:90,180,450,900mg/kgAdministration:Oralgavage(p.o.),Intraperitonealinjection(i.p.)(p.o.onday1,once(180and900mg/kg),i.p.forthenext2days,onceaday(90and450mg/kg),dissolvedin0.01%acetone)Result:Significantlyincreasedsuperoxidedismutase(SOD)andmalondialdehyde(MDA)levelsinthelungsandliver,serum8-hydroxy-2'-deoxyguanosine(8-OHdG),andtheexpressionoftumornecrosisfactor-α(TNF-α)andinterleukin-6(IL-6)(highdosegroup:1/2 MasterofBioactiveMolecules—您身邊的抑制劑大師www.MedChemE450mg/kg+900mg/kg).Significantlydecreasedtheexpressionoftransforminggrowthfactor-β(TGF-β)andforkheadboxtranscriptionfactor3(Foxp3)(highdosegroup:450mg/kg+900mg/kg).AnimalModel:Chineserareminnows(Gobiocyprisrarus)[4]Dosage:10,100,1000μg/LAdministration:Exposurefor30daysResult:Increasedthefrequencyofliverdamageandhepatocyteapoptosis,aswellastheenzymeactivityofcaspase9andcaspase3inlivertissues.REFERENCESSunK,etal.SubcellulardistributionandbiotransformationofphenanthreneinpakchoiafterinoculationwithendophyticPseudomonassp.asprobedusingHRMScoupledwithisotope-labeling.EnvironPollut.2018Jun;237:858-867.DupuyJ,etal.Effectandlocalizationofphenanthreneinmaizeroots.Chemosphere.2016Apr;149:130-6.MaH,etal.Effectsofphenanthreneonoxidativestressandinflammationinlungandliveroffemalerats.EnvironToxicol.2020Jan;35(1):37-46.HongX,etal.Phenanthrene-InducedApoptosisandItsUnderlyingMechanism.EnvironSciTechnol.2017Dec19;51(24):14397-14405.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplicat