Proglumide-sodium-Standard-生命科學試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEProglumidesodium(Standard)Cat.No.:HY-103354RCASNo.:99247-33-3分?式:C??H??N?NaO?分?量:356.39作?靶點:CholecystokininReceptor作?通路:GPCR/GProtein;NeuronalSignaling儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Proglumide(sodium)(Standard)Proglumide(sodium)的分析標準品。本產(chǎn)品?于研究及分析應?。Proglumidesodium?種?肽和?服活性膽囊收縮素(CCK)-A/B受體拮抗劑。Proglumidesodium選擇性阻斷CCK在中樞神經(jīng)系統(tǒng)中的作?。Proglumidesodium具有抑制胃分泌和保護胃??指腸粘膜的能?，還具有抗癲癇和抗氧化活性。IC50&TargetCholecystokinin(CCK)-A/Breceptors[1][2]REFERENCES[1].AhmadM,etal.Theeffectsofquinacrine,proglumide,andpentoxifyllineonseizureactivity,cognitivedeficit,andoxidativestressinratlithium-pilocarpinemodelofstatusepilepticus.OxidMedCellLongev.2014;2014:630509.[2].IwamotoY,etal.Invitroandinvivoeffectofproglumideoncholecystokinin-stimulatedamylasereleaseinmousepancreaticacini.GastroenterolJpn.1984Feb;19(1):53-8.[3].González-PugaC,etal.SelectiveCCK-AbutnotCCK-BreceptorantagonistsinhibitHT-29cellproliferation:synergismwithpharmacologicallevelsofmelatonin.JPinealRes.2005Oct;39(3):243-50.[4].BunneyBS,etal.Furtherstudiesonthespecificityofproglumideasaselectivecholecystokininantagonistinthecentralnervoussystem.AnnNYAcadSci.1985;448:345-51.[5].TariqM,etal.Gastricandduodenalantiulcerandcytoprotectiveeffectsofproglumideinrats.JPharmacolExpTher.1987May;241(2):602-7.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-5895