眼科學(xué)基礎(chǔ)：眼生理學(xué)

1、 1、掌握：眼生理學(xué)關(guān)鍵基礎(chǔ)知識內(nèi)容、整體思路 和進展方向。 2、熟悉：眼科生理學(xué)的細胞水平研究進展和基本 專業(yè)英文詞匯。 3、了解：眼生理學(xué)分子水平的研究進展和最新動 態(tài)。 問題內(nèi)容理解問題思考 EYE stroma=water soluble 角膜內(nèi)皮細胞的泵角膜內(nèi)皮細胞的泵- -漏系統(tǒng)漏系統(tǒng) Descemets MembraneDescemets Membrane Feature: transparence, metabolic, penetrability, wound healing, perception, limbal stem cells 24-hour healing Reg

2、eneration: yes 24-hour healing regeneration regenerationRegeneration: No! Descemets MembraneDescemets Membrane Regenerated by endothelium 300-500 cells/mm2 Corneal nerves Temperature Pain Pressure Feature: transparence, metabolic, penetrability, wound healing, perception, limbal stem cells 24-hour h

3、ealing Regeneration: yes Descemets MembraneDescemets Membrane Q1: What is the stem cells? Q2: How to use? Q3: Transplantation? ES cells iPS cells Function: protection Feature: elasticity, shading, wound healing Nerves in sclera Collagen fibers Myopia research Ciliary epithelium posterior chamber (PC

4、) anterior chamber (AC) Trabecular outflow：trabecular meshwork Schlemms canalcollector channel intrascleral vein Uveoscleral outflow：ciliary band ciliary muscleciliary boday and suprachoroidal space (1020) Iris (5) PC AC Function: medium, nutrient, IOP Feature: dynamic, blood aqueous barrier Ciliary

5、 body (CB) Ciliary epithelium PCPupilAC Trabecular mesh Schlemm Collector Ciliary band Ciliary muscle Ciliary body, suprachoroidal space Scleral collegan 20% Trabecular outflow Uveoscleral outflow 75% Intrascleral vein Rate of aqueous production (ciliary body) Resistance of aqueous outflow(trabecula

6、r meshwork) Episcleral venous pressure productionoutflow Intraocular contentseyeball wall Normal IOP: maintain normal visual function Range: 1021mmHg （1.33 2.79kPa） Stable and symmetric balloon 21 24mmHg（3.20kPa） Between-eye difference 5mmHg(0.665kPa) Difference 8mmHg(1.064kPa) within 24hrs Disease (non-trauma)-organ-pathology- -pathophysiology-protein-RNA- DNA-epigenetics