兒科泌尿系統(tǒng)NS英文

1、 Nephrotic Syndrome(NS) Definition NS is an accumulation of symptoms and signs and is characterized by proteinuria, hypoproteinemia, edema, and hyperlipidemia. Definition In children under age 5 years the disease usually takes the form of idiopathic (primary) NS of childhood. Conditions Of Attack Se

2、cond only to acute nephri- tisIncidence age: at all ages, but most commonly between 35 years of age Type 1. Clinical type Simple type NS ; Nephritic NS 2. Response to steroid therapy (P274) Type The initial response to cortico- steroids is a guide to prognosis Steroid-dependent NS Steroid-responsive

3、 NS Steroid-resistant NS Type Total effect Partial effect Non-effect Type 3. Pathologic type (P282) Minimal change disease, MCD 80% of all NS, little change on light microscopy, Type but electron microscopy shows effacement of foot processes (podocytes) of epithelial cells Type Other forms (Non-MCNS

4、) MSPGN, FSGN, MGN, MPGN, etc. Pathogenesis The primary disorder is an increase in glomerular permeability to plasma proteinsloss of proteins, mainly albumin in urine Pathogenesis Filtrated barrier Charge barrier Molecular barrier The loss of the negative charges on the GBM Pathogenesis The underlying pathogenesis is unknown, but evidence strongly supports the impor- tance of immune mechanisms (P281) Thank yo