納米多孔羥基磷灰石的制備方法及其在藥物載體方面應(yīng)用的研究進展

1、 1022 沈 陽 藥 科 大 學 學 報 第 27 卷 26 TAYADE N G. Studies on nove l drug de live ry syste ms fo r anti m a larial drugs D . M aharashpra : M um ba, i 2006 . 27 CHO I W J , KI M J K, CHO I S H, e t a . l Low tox ic ity of catconic lipid based emu lsion for gene transfer J. B io m ater ials , 2004, 25( 27:

2、5893- 5903. 28 TAM ILVANAN S, SCHM IDT S, M LLER RH, et a.l In vitro adso rption o f plasm a pro teins onto the surface ( cha rges mod ified subm icroe m ulsion for intrav enous adm inistration J. Eur J Pha r m B iophar m, 2005 , 59 ( 1: 1- 7. 29 Y EEPRAE W, KAWAKAM I S, H I GU CH I Y, et a. l B io

3、distribution character istics o fm anno sy la ted and fucosy la ted O /W e m ulsions in m ice J . J D rug T arget , 2005, 13( 8- 9: 479- 487. Research progress on drug loaded intravenous lipid e m ulsions ZHAO M in g m ing, SU M in, TANG X ing ( Schoo l o f P ha r m acy, Shenyang Pharm aceutica l Un

4、 iversity, Shenyang 110016 , C hina Abstract : Objective T o summ ar ize th e research prog ress on drug lo aded in travenous lip id em ulsio ns as a nove l drug carrier . M ethods Represen tative papers recently pub lished w ere consulted , analyzed and summ a rized . R esults T he preparation m at

5、erials and techno logy, th e ev aluat io n m ethods, the clin ica l app lications and th e future pro spects w ere rev iew ed. Conclusion s T he drug loaded intravenous lip id em ulsio ns are prom ising fo r the further clin ica l applica tio n and have broad deve lop m ent in the future. K ey w ord

6、 s : drug loaded in travenous lip id e m ulsion ; preparation; app lication ( 上接第 1013 頁 Research Progress on synthesis and characterization of nanoporous hydroxyapatite as drug carriers ZHAO Q in fu , ZH ENG L , i W ANG S i ling ( Schoo l o f P ha r m acy, Shenyang Pharm aceutica l Un iversity, She

7、nyang 110016 , C hina Abstract : Objective T o su mm arize the recen t preparat io n m ethod and the pace o f pro gre ss in th e nanopo rous hydroxyapatite as drug carries . M ethods B ased on re levant literatures , the la test researche s are repo rted . T he preparat io n m ethod and properties a

8、s carriesw ere rev iew ed , respectiv ely. R esu lts The m ain dev elop m en t tendency of nanoporous hydro xyapatite a s drug carriesw as po in ted ou. t C on clu sions N anopo ro us hydroxyap atite w ith variousm o rpho lo g ie s and surface properties hav e a lso been extensive ly applied as drug carriers o f a variety o f phar m aceut ica lm o lecules especially fo r biom acrom o lecules and inso lub le drug because o f th e ir ex ce llen t b io com pa tib ility, nontox ic ity, large specif