CST公司信號通路圖NF-kB

1、NF- k B Sig nalingTNFIL-1Ag-MHCIL-1RTNFRAgTLRsGF-Rsi.nRasIRAK1/4wiA20RIPubCYLDTAX1BP1PI3KPDK1TAB2/3ubTAB1/2TAK1TAK1Taxub性TrCPub性TrCPJNKububCKIIRelA/cRelubp38UVMSK1RSK1PKAcYLDubBcl-3PCAFSUMOHDAFor detailed signaling see TLR Pathway.Genotoxic StressCBP/ p300p65/ RelAp65/ RelAp65/RelA kB2IKK YNEMOProte

2、asomal DegradationNF- K p50/52ubTRAF6Nuclear-cytoplasmic shuttling of nonphosphorylated formsAktCot rPellinoTCR /l l'lNF-出 p50/52Nucle usub K48-ubiquitinLPS, CpG, ssRNA, dsRNANAP1 NAKIKK y NEMOub K63-ubiquitinRelA/cRel IFor detailed signaling see BCR Pathway.ubt ubc5PIASy ATM PARP1kB aNF- p52cyt

3、°PlasmARStress: ROIs, UV, metals, ischemia, shearSUMO IKK YNEMOCKIIa /NF- KB p50/52NF- KB p50/52Tubc13For detailed signaling, TRAF6 see TCR Pathway. UEV1APKC Z(GSK-3 BELKS IKK B IKK a IKK y/ - ' NEMO ubGrowth Factors: BMP, EGF, HGH, Insulin, NGF, TGF- aIKK ahIKK aIKK a IKK a/ £BCR;I I-

4、.1Survival, Proliferation, Inflammation, Immune RegulationLT, CD40L, BAFF/BLysLT R,D40R3JQ B 3TARTubNF-岀2<p100RelBVProteasomalProcessingRelBNF- kB2<p52常ReBLymphogenesis, B Cell Maturation? 20032010 Cell Sig nali ng Tech no logy, I nc.NF- k B Signaling ? created January 2003 ? revised November

5、2010Cell SignalingSign ali ng Pathways KeyKin asePhosphatase> Direct Stimulatory Modificati on1 Direct In hibitory Modificati onTran scripti on FactorCaspaseReceptorEn zymeCycli n, pro-apoptoticpro-survivalGAP/GEFJoining of Subun itsGTPaseG-prote in, ribosomal sub un itAcetylaseDeacetylase2003 - 2010 Cell Sig nali ng Tech no logy, I nc.Multistep Stimulatory Modificati on Multistep In hibitory Modificatio n Ten tative Stimulatory Modificati on Ten tative In hibitory Modificati on Transcriptional Stimulati