物理藥劑學(xué)學(xué)習(xí)教案

1、會(huì)計(jì)學(xué)1物理物理(wl)藥劑學(xué)藥劑學(xué)第一頁(yè)，共74頁(yè)。classParticle sizeCharacteristics of systemexampleMolecular dispersionLess than 1 nmInvisible in electron microscope Pass through ultrafilter and semipermeable membrane undergo rapid diffusionOxygen molecules, ordinary ions, glucoseColloidal dispersionFrom 1 nm to o.5 mNot

2、 resolved by ordinary microscope (although may be detected under ultramicroscope) Visible in electron microscopePass though filter paperDo not pass semipermeable membrane Diffusion very slowly Colloidal silver sols, natural and synthetic polymers, cheese, butter, jelly, milk, etc.Coarse dispersionGr

3、eater than o.5 mVisible under microscopeDo not passthough normal filter paper Do not dialyze though semipermeable menmbraneDo not diffusionGrains of sand,most pharmaceutical emulsions and suspension, red blood cells第1頁(yè)/共74頁(yè)第二頁(yè)，共74頁(yè)。Lyophilic colloidsLyophobic colloidsAssociation colloids第2頁(yè)/共74頁(yè)第三頁(yè)，

4、共74頁(yè)。colloidal system in one liquid(e.g. water) may not do so in another liquid(e.g. benzene).第3頁(yè)/共74頁(yè)第四頁(yè)，共74頁(yè)。第4頁(yè)/共74頁(yè)第五頁(yè)，共74頁(yè)。第5頁(yè)/共74頁(yè)第六頁(yè)，共74頁(yè)。第6頁(yè)/共74頁(yè)第七頁(yè)，共74頁(yè)。第7頁(yè)/共74頁(yè)第八頁(yè)，共74頁(yè)。第8頁(yè)/共74頁(yè)第九頁(yè)，共74頁(yè)。第9頁(yè)/共74頁(yè)第十頁(yè)，共74頁(yè)。第10頁(yè)/共74頁(yè)第十一頁(yè)，共74頁(yè)。第11頁(yè)/共74頁(yè)第十二頁(yè)，共74頁(yè)。第12頁(yè)/共74頁(yè)第十三頁(yè)，共74頁(yè)。2第13頁(yè)/共74頁(yè)第十四頁(yè)，共74頁(yè)。第14頁(yè)/共74頁(yè)第

5、十五頁(yè)，共74頁(yè)。第15頁(yè)/共74頁(yè)第十六頁(yè)，共74頁(yè)。第16頁(yè)/共74頁(yè)第十七頁(yè)，共74頁(yè)。第17頁(yè)/共74頁(yè)第十八頁(yè)，共74頁(yè)。第18頁(yè)/共74頁(yè)第十九頁(yè)，共74頁(yè)。第19頁(yè)/共74頁(yè)第二十頁(yè)，共74頁(yè)。第20頁(yè)/共74頁(yè)第二十一頁(yè)，共74頁(yè)。Cylindrical micelleBilayerBilayer vesicleInverted micelleMicrotubule第21頁(yè)/共74頁(yè)第二十二頁(yè)，共74頁(yè)。ExampleType Compound Amphiphile Gegenions Anionic Sodium lauryl sulfateCH3(CH2)11OSO3-Na

6、+Cationic Cetyl trimethyl-ammonium bromideCH3(CH2)15N+(CH3)3Br-Nonionic Polyoxyethylene laury etherCH3(CH2)10CH2O(CH2OCH2)23HAmpholytic Dimenthyldodecy lammonio-propane sulfonateCH3(CH2)11N+(CH3)2(CH2)3OSO2-第22頁(yè)/共74頁(yè)第二十三頁(yè)，共74頁(yè)。第23頁(yè)/共74頁(yè)第二十四頁(yè)，共74頁(yè)。To determine the minimum amount of surfactant第24頁(yè)/共74

7、頁(yè)第二十五頁(yè)，共74頁(yè)。第25頁(yè)/共74頁(yè)第二十六頁(yè)，共74頁(yè)。第26頁(yè)/共74頁(yè)第二十七頁(yè)，共74頁(yè)。第27頁(yè)/共74頁(yè)第二十八頁(yè)，共74頁(yè)。第28頁(yè)/共74頁(yè)第二十九頁(yè)，共74頁(yè)。第29頁(yè)/共74頁(yè)第三十頁(yè)，共74頁(yè)。第30頁(yè)/共74頁(yè)第三十一頁(yè)，共74頁(yè)。第31頁(yè)/共74頁(yè)第三十二頁(yè)，共74頁(yè)。第32頁(yè)/共74頁(yè)第三十三頁(yè)，共74頁(yè)。The first satisfactory theoretical treatment of Brownian motion was made by Albert Einstein in 1905. 第33頁(yè)/共74頁(yè)第三十四頁(yè)，共74頁(yè)。D=RT6NAp

8、hr第34頁(yè)/共74頁(yè)第三十五頁(yè)，共74頁(yè)。第35頁(yè)/共74頁(yè)第三十六頁(yè)，共74頁(yè)。第36頁(yè)/共74頁(yè)第三十七頁(yè)，共74頁(yè)。sedimentationdiffusion第37頁(yè)/共74頁(yè)第三十八頁(yè)，共74頁(yè)。第38頁(yè)/共74頁(yè)第三十九頁(yè)，共74頁(yè)。M=RTSD(1-vr)Sedimentation is normally very slow, but it can be accelerated by ultracentrifugation, a technique that replaces the gravitational field with a centrifugal field.Wh

9、ere R is the gas constant, S is the sedimentation coefficient, the unit Svedberg is 1 X 10-13 second, T is the absolute temperature, D is the diffusion constant, v is the volume of 1 g of particle, is the density of medium. 第39頁(yè)/共74頁(yè)第四十頁(yè)，共74頁(yè)。第40頁(yè)/共74頁(yè)第四十一頁(yè)，共74頁(yè)。第41頁(yè)/共74頁(yè)第四十二頁(yè)，共74頁(yè)。第42頁(yè)/共74頁(yè)第四十三頁(yè)，共7

10、4頁(yè)。第43頁(yè)/共74頁(yè)第四十四頁(yè)，共74頁(yè)。第44頁(yè)/共74頁(yè)第四十五頁(yè)，共74頁(yè)。第45頁(yè)/共74頁(yè)第四十六頁(yè)，共74頁(yè)。第46頁(yè)/共74頁(yè)第四十七頁(yè)，共74頁(yè)。第47頁(yè)/共74頁(yè)第四十八頁(yè)，共74頁(yè)。第48頁(yè)/共74頁(yè)第四十九頁(yè)，共74頁(yè)。Energy（+）（-）Repulsion , VRComposite , VTPotential barrierInterparticle distancePrimary minimum(atrraction)Atrractive ,VASecondary minimum(atrraction)第49頁(yè)/共74頁(yè)第五十頁(yè)，共74頁(yè)。第50頁(yè)/共74頁(yè)

11、第五十一頁(yè)，共74頁(yè)。第51頁(yè)/共74頁(yè)第五十二頁(yè)，共74頁(yè)。第52頁(yè)/共74頁(yè)第五十三頁(yè)，共74頁(yè)。第53頁(yè)/共74頁(yè)第五十四頁(yè)，共74頁(yè)。Association colloidsDrug 第54頁(yè)/共74頁(yè)第五十五頁(yè)，共74頁(yè)。第55頁(yè)/共74頁(yè)第五十六頁(yè)，共74頁(yè)。Tween 20Peppermint oilWater 010010001000505050Increasing quantity of water第56頁(yè)/共74頁(yè)第五十七頁(yè)，共74頁(yè)。第57頁(yè)/共74頁(yè)第五十八頁(yè)，共74頁(yè)。第58頁(yè)/共74頁(yè)第五十九頁(yè)，共74頁(yè)。第59頁(yè)/共74頁(yè)第六十頁(yè)，共74頁(yè)。第60頁(yè)/共74頁(yè)第六十一頁(yè)，共74頁(yè)。Hydrogels第61頁(yè)/共74頁(yè)第六十二頁(yè)，共74頁(yè)。第62頁(yè)/共74頁(yè)第六十三頁(yè)，共74頁(yè)。第63頁(yè)/共74頁(yè)第六十四頁(yè)，共74頁(yè)。第64頁(yè)/共74頁(yè)第六十五頁(yè)，共74頁(yè)。第