基于Matlab智能算法的GERD中藥治療方案優(yōu)選

1、基于Matlab智能算法的胃食管返流病中藥治療方案優(yōu)選About GERDHigh Incidence Rate (5.2%-8.5% in east Asia after 2005)Three sub typesAcid reflux and heartburnLoss of control by PPIsHerbs are a good alternative choiceGood to be evaluated by symptom scores, which is somehow like TCM evaluationPossible to be prescribed by machi

2、ne based on studyANN is an important way to realize thatRough set used for the diagnosis of GERDAfter the diagnosis, then?Where is the corresponding treatments?What is ANN?Artificial neural networks (ANNs), a form of connectionism, are computing systems inspired by the biological neural networks tha

3、t constitute animal brains. Such systems learn (progressively improve performance) to do tasks by considering examples, generally without task-specific programming. For example, in image recognition, they might learn to identify images that contain cats by analyzing example images that have been man

4、ually labeled as cat or no cat and using the analytic results to identify cats in other images. They have found most use in applications difficult to express in a traditional computer algorithm using rule-based programming.?Why we need?1. AI challenges increased in human society, including those tra

5、ditional fields;2. The idea of TCM has big possibility to be simulated by ANN.3. The development of some toolbox make it easier to make research into this field.4. Matlab is a good tool for Simulink and explore the possibility of “Treatment based on symptoms recognition”. Human Training and Machine

6、Study1. Different Study curve2. Different Capacity of study3. Different precision of acquiring knowledge4. Different utilization powera3=f3(LW3,2f2(LW2,1f1(IW1,1pb1)b2)b3)=y Correspondance Bwteen Symptoms and HerbsD1D2DnS1S1SmFrequency normalized0,1（xmin）/(maxmin)Memory Weight MatrixX= Memory weight

7、 matrixS1:0.3636;S2:0.2273;S3:0.2182;S4:0.5272;S5:0.0909;S6:0.0455;S7:0.4545;S8:0.2273;S9:0.3636;S10:0.4909;S11:0.0455;S12:0.0818。Lower threshold of selectionSymptoms and Herbs SetsSay s1=中酸，s2=嘈雜，s3=反胃，s4=嘔吐，s5=胸痹，s6=梅核氣，s7=胸痞，s8=嘔逆，s9=胃痞，s10=納差，s11=脅痛，s12=噯氣。藥物d1=陳皮，d2=甘草，d3=白術(shù)，d4=半夏，d5=蒼術(shù)，d6=茯苓，d

8、7=人參，d8=生姜，d9=神曲，d10=吳萸，d11=砂仁，d12=黃連。Composition of any four symptoms:MatLab program: combntns(1,2,3,4,5,6,7,8,9,10,11,12,4)S1=1 1 1 1 0 0 0 0 0 0 0 0;S2=1 1 1 0 0 1 0 0 0 0 0 0;S3=1 1 1 0 0 0 0 1 0 0 0 0;D1=1 1 1 1 1 1 0 1 0 1 0 1;D2=1 1 1 1 1 1 0 1 0 1 0 1;D3=1 1 1 1 1 1 0 1 0 1 0 1;S=S1;S2;S3;D=

9、D1;D2;D3;net=newff(0,1;0,1;0,1;0,1;0,1;0,1;0,1;0,1;0,1;0,1;0,1;0,1,5,3,12,tansig,tansig,tansig);Symptoms setBP networkTraining and SimulinkTrain function for training and Sim function for Simulink:After around 3090 paces, the error is almost approaching 0Case Test 1The patient has反酸，胃痞，納差，噯氣symptoms

10、，so the symptoms set would be：S4=1 0 0 0 0 0 1 0 1 0 0 1;D4=sim(net,S4)結(jié)果顯示應(yīng)該采用的藥物為陳皮，半夏，蒼術(shù)，黃連，基本勾勒出了蒼連丸（見古今醫(yī)鑒卷五）的主要成份。蒼連丸由蒼術(shù)、陳皮、半夏、黃連、茯苓、吳萸六味藥組成，用治郁積吞酸?；颊咴诜此岬耐瑫r癥見胃痞、納差、噯氣，恰為郁積的表現(xiàn)，因此基本符合蒼連丸的應(yīng)用指征。Case Test 2Patient 2 has嘈雜，胸痹，脅痛，噯氣symptoms，the symptoms set would be:S5=0 1 0 0 1 0 0 0 0 0 1 1;D5=sim(net,S5)據(jù)其輸出結(jié)果，可選用的藥物為陳皮，甘草，白術(shù)，半夏，蒼術(shù)，茯苓，生姜，吳萸，黃連，基本包含了二陳、左金等對治之劑，能夠較好地體現(xiàn)中醫(yī)的辨證論治思想。上述過程的輸出層也可應(yīng)用硬限幅函數(shù)“hardlim”，則結(jié)果將以“0”或“1”的二值形式出現(xiàn)，0表示該藥不選用，1表示選用該藥。Programed Realization of TCM D&T對于一種疾病，首先要通過大量學(xué)習(xí)樣本的研究，得出哪些為該病的主要癥狀及證型，然后通過Rough集分