4-Methylchrysoeriol _Cytochrome P450 抑制劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE4-MethylchrysoeriolCat. No.: HY-112734CAS No.: 4712-12-3分式: CHO分量: 314.29作靶點(diǎn): Cytochrome P450作通路: Metabolic Enzyme/Protease儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 20.83 mg/mL (66.28

2、 mM; Need ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (6.62 mM); Suspended solution; Need ultrasonicBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE物活性 4-Methylchrysoeriol有效的細(xì)胞素 P450 酶 (P450) 的抑制劑，其對(duì) P450 1B1 依賴的氧基烯丙醇-O-脫基酶 (EROD) 的 IC50 值為 19 nM。IC50

3、 & Target IC50: 19 nM ( human P450 1B1-dependent EROD) 1.體外研究 4-Methylchrysoeriol (34DM57DHF) is a potent inhibitor of P450 enzymes, particularly for P450 1B1, with anIC50 of 19 nM for human P450 1B1-dependent EROD 1.REFERENCES1. Shimada T, et al. Reverse type I binding spectra of human cytochrome P

4、450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene,phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study. Chem Res Toxicol. 2009Jul;22(7):1325-33.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 021-