Calcitonin-Gene-Related-Peptide-CGRP-83-119-rat-TFA-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECalcitonin Gene Related Peptide (CGRP) (83-119), rat TFACat. No.: HY-P1462A分式: CHNOS.CHFO分量: 3920.32Sequence: Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Th

2、r-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2 (Disulfide bridge: Cys2-Cys7)Sequence Shortening: SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2(Disulfide bridge: Cys2-Cys7)作靶點(diǎn): CGRP Receptor作通路: GPCR/G Protein; Neuronal Signaling儲存式: Stored under nitrogenPowder -80C 2 years-20C 1 yearIn solvent -80C 6 months-20C 1 mo

3、nth* 該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)現(xiàn)配，即刻使。BIOLOGICAL ACTIVITY物活性 Calcitonin Gene Related Peptide (CGRP) (83-119), rat (TFA)種由 37 個氨基酸組成的降鈣素家族神經(jīng)肽，通過 (CRLR) 起作。IC50 & Target CRLR 1.體外研究 Calcitonin Gene Related Peptide (CGRP) (83-119), rat (TFA) belongs to the calcitonin family ofneuropeptides which also includes ad

4、renomedullin, amylin, calcitonin, intermedin and calcitonin receptor-stimulating peptide. Calcitonin Gene Related Peptide (CGRP) has two isoforms (CGRP and CGRP), andacts through calcitonin receptor-like receptor (CRLR) 1. Calcitonin Gene Related Peptide (CGRP) plays akey role in migraine pathophysi

5、ology and is associated with activation of the trigeminovascular system.CGRP prossibly acts postjunctionally in these areas putatively involved in primary headaches 2.體內(nèi)研究Calcitonin Gene Related Peptide (CGRP) (83-119), rat (TFA) is a potent inducer of oedema in rat orofacialtissue. CGRP (100 L; 8-3

6、3 pM) induces a rapidly developing (5-15min) and long-lasting (6h), dose-1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEdependent oedema in the rat cheek. CGRP induces a smaller oedematogenic effect in the rat hind paw alsoblocked by the CGRP antagonist. CGRP (16 pM) potentiates the oedema induced

7、 by co-injected substanceP (3.7 nM) 3.PROTOCOLAnimal Rats 3Administration 3 Male Wistar rats, weighing 150-250 g, are used throughout this study. As soon as the righting reflex is lost,the initial (t=0) measurement of cheek thickness (in mm) is made with digital calipers, the intra-oral injectiongiv

8、en and then cheek thickness measured again at 5, 15 and 30 min, 1, 2, 3, 4, 6 and 24 h, followingagonists ( Calcitonin Gene Related Peptide (CGRP) (83-119), rat (TFA), etc) or saline injections. Cheekthickness in -carrageenan (CG)-injected animals is measured at 0, 15, 30 min, 1, 2, 3, 4, 5, 6 and 2

9、4 h. Pawthickness (in mm) is obtained similarly, using the calipers at the time points indicated for cheek oedema, withthe only difference being that the animals are not anesthetized for local (intraplantar) injections 3.MCE has not independently confirmed the accuracy of these methods. They are for

10、 reference only.REFERENCES1. S. Ghatta, et al. Calcitonin gene-related peptide: Understanding its role. Educational Forum. 20.6.2004.2. Eftekhari S, et al. Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus andspinal cord at C1-level. BMC Neurosci. 2011 Nov 10;12:112.3. Queiroz BFG, et al. Calcitonin-gene related peptide is a potent inducer of oedema in rat orofacial tissue. Neuropeptides. 2018 Apr;68:43-48.McePdfHeightCaution: Product has not been f