Nicardipine-Hydrochloride-YC-93-Hydrochloride-DataSheet-生命科學試劑-MedChemExpressVIP

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemENicardipine HydrochlorideCat. No.: HY-12515ACAS No.: 54527-84-3Synonyms: YC-93 Hydrochloride分式: CHClNO分量: 515.99作靶點: Calcium Channel; Autophagy作通路: Membrane Transporter/Ion Channel; Neuronal Signaling;Autophagy儲存式: 4C, protect f

2、rom light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性數(shù)據(jù)體外實驗 DMSO : 35 mg/mL (67.83 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 1.9380 mL 9.6901 mL 19.3802 mL5 mM 0.3876 mL 1.9380 mL 3.8760 mL10 mM 0.1938 mL 0.9690 mL 1.9380 mL請

3、根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (4.85 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90%

4、 (20% SBE-CD in saline)Solubility: 2.5 mg/mL (4.85 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Nicardipine Hydrochloride (YC-93 Hydrochloride)種鈣通道拮抗劑，已被泛應于控制的嚴重 壓等疾病，缺性中風，腦外傷，腦出等。戶使本產(chǎn)品發(fā)表的科研獻 Biosci Rep. 2019 Jun 20. Int J Clin Exp Med. 2019;12(5):5184-5

5、190.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Huang BR, et al. Anti-neuroinflammatory effects of the calcium channel blocker nicardipine on microglial cells: implications forneuroprotection. PLoS One. 2014 Mar 12;9(3):e91167.2. Amenta F, et al. Vascular and neuronal hyper

6、tensive brain damage: protective effect of treatment with nicardipine. J Hypertens Suppl.1996 Oct;14(3):S29-35.3. Gasior M, et al. Influence of nicardipine, nimodipine and flunarizine on the anticonvulsant efficacy of antiepileptics againstpentylenetetrazol in mice. J Neural Transm. 1996;103(7):819-31.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 40