plus-Bicuculline-d-Bicuculline-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE(+)-BicucullineCat. No.: HY-N0219CAS No.: 485-49-4Synonyms: d-Bicuculline分式: CHNO分量: 367.35作靶點: GABA Receptor作通路: Membrane Transporter/Ion Channel; Neuronal Signaling儲存式: 4C, protect from light* In solvent : -80C, 6 months; -20C

2、, 1 month (protect fromlight)溶解性數(shù)據(jù)體外實驗 DMSO : 36 mg/mL (98.00 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.7222 mL 13.6110 mL 27.2220 mL5 mM 0.5444 mL 2.7222 mL 5.4444 mL10 mM 0.2722 mL 1.3611 mL 2.7222 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。

3、體內(nèi)實驗請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.81 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL

4、 (6.81 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (6.81 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 (+)-Bicuculline是對光敏感的GABA-A 受體競爭型拮抗劑。戶使本產(chǎn)品發(fā)表的科研獻 J Pain. 2019 May;20(5):577-591.See more customer validations on HYPERLI

5、NK / www.MedChemEREFERENCES1. Zahm DS, et al. Comparison of the locomotor-activating effects of bicuculline infusions into the preoptic area and ventral pallidum. BrainStruct Funct. 2014 Mar;219(2):511-26.2. Johnston GA. Advantages of an antagonist: bicuculline and other GABA antagonists. Br J Pharmacol. 2013 May;169(2):328-36.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 0