PGD2-IN-1-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPGD2-IN-1Cat. No.: HY-101430CAS No.: 885066-67-1分式: CHClNO分量: 460.35作靶點: Others作通路: Others儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 25 mg/mL (54.31 mM)* means soluble, but saturation

2、unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.1723 mL 10.8613 mL 21.7226 mL5 mM 0.4345 mL 2.1723 mL 4.3445 mL10 mM 0.2172 mL 1.0861 mL 2.1723 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 PGD2-IN-1DP受體拮抗劑, 來專利專利WO 2006044732 A2，化合物實例15 (d)， IC50值為0.3 nM。IC50 & T

3、arget IC50: 0.3 nM 1體外研究Prostaglandin D2 (PGD2) is a major inflammatory mediator implicated in asthma and allergic rhinitis. It islargely produced as the major cyclooxygenase metabolite upon allergen-provoked degranulation from mast1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEcells. Blockage of

4、PGD2 using DP antagonistshave been shown to be effective at alleviating the symptoms ofallergic rhinitis in multiple species and more specifically have been shown to inhibit the antigen-induced nasalcongestion 1.REFERENCES1. Patent: WO/2006/044732A22. Mu L, et al. Understanding DP receptor antagonism using a CoMSIA approach. Bioorg Med Chem Lett. 2011 Jan 1;21(1):66-75.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;F