ML228-CID-46742353-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEML228Cat. No.: HY-12754CAS No.: 1357171-62-0Synonyms: CID-46742353分式: CHN分量: 415.49作靶點: HIF/HIF Prolyl-Hydroxylase作通路: Metabolic Enzyme/Protease儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO

2、 : 35 mg/mL (84.24 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.4068 mL 12.0340 mL 24.0680 mL5 mM 0.4814 mL 2.4068 mL 4.8136 mL10 mM 0.2407 mL 1.2034 mL 2.4068 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依?/p>

3、添加助溶劑(為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.02 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (6.02 mM); Clear solution1/2 Master of Sma

4、ll Molecules 您邊的抑制劑師www.MedChemE3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (6.02 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 ML228(CID-46742353)是HIF信號通路活化劑，可活化HIF以及下游EGFR。戶使本產(chǎn)品發(fā)表的科研獻 Exp Ther Med. 2017 Mar;13(3):861-866.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1

5、. Theriault JR, et al. Discovery of a Small Molecule Activator of the Hypoxia Inducible Factor Pathway. Probe Reports from the NIHMolecular Libraries Program.2. Theriault JR, et al. Discovery of a new molecular probe ML228: an activator of the hypoxia inducible factor (HIF) pathway. Bioorg MedChem Lett. 2012 Jan 1;22(1):76-81.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 0