Lithocholic-acid-3α-Hydroxy-5β-cholanic-acid-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELithocholic acidCat. No.: HY-B0172CAS No.: 434-13-9Synonyms: 3-Hydroxy-5-cholanic acid分式: CHO分量: 376.57作靶點(diǎn): Autophagy; Endogenous Metabolite作通路: Autophagy; Metabolic Enzyme/Protease儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -8

2、0C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 150 mg/mL (398.33 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.6555 mL 13.2777 mL 26.5555 mL5 mM 0.5311 mL 2.6555 mL 5.3111 mL10 mM 0.2656 mL 1.3278 mL 2.6555 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)

3、 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (6.64 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (6.64 mM); Clear soluti

4、on1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Lithocholic acid有毒的次級(jí)膽汁酸，能促使肝內(nèi)膽汁淤積，能促進(jìn)腫瘤發(fā)。IC50 & Target Human Endogenous Metabolite戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Cell Res. 2019 Mar;29(3):193-205. Br J Pharmacol. 2019 Jul;176(13):2162-2178. Sci Rep. 2017 Aug 30;7(1):9967. Food Chem Toxicol. 20

5、18 Jul 14;120:253-260.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Jenkins, D.J., et al., Effect on blood lipids of very high intakes of fiber in diets low in saturated fat and cholesterol. N Engl J Med, 1993.329(1): p. 21-6.2. Goldberg, A.A., et al., Lithocholic bile acid s

6、electively kills neuroblastoma cells, while sparing normal neuronal cells. Oncotarget, 2011.2(10): p. 761-82.3. Matsubara, T., et al., TGF-beta-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury. J Lipid Res, 2012. 53(12): p. 2698-707.4. Yang R, et al. Metabolomic analysis of cholestatic liver damage in mice. Food Chem Toxicol. 2018 Jul 14;120:253-260.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.T