Prasugrel-hydrochloride-PCR-4099-hydrochloride-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPrasugrel hydrochlorideCat. No.: HY-15284ACAS No.: 389574-19-0Synonyms: PCR 4099 (hydrochloride)分式: CHClFNOS分量: 409.9作靶點(diǎn): P2Y Receptor作通路: GPCR/G Protein儲(chǔ)存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (pr

2、otect fromlight)溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 41.67 mg/mL (101.66 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.4396 mL 12.1981 mL 24.3962 mL5 mM 0.4879 mL 2.4396 mL 4.8792 mL10 mM 0.2440 mL 1.2198 mL 2.4396 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先

3、配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (5.07 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (5.07 mM); Clear solution3.

4、請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (5.07 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Prasugrel hydrochloride (PCR 4099 hydrochloride)板抑制劑，IC50 為 1.8 M。IC50 & Target P2Y12 receptor.體外研究 Prasugrel (PCR 4099) is a novel platelet inhibit

5、or used for the reduction of thrombotic cardiovascular events(including stent thrombosis) in patients with acute coronary syndrome who are to be managed with PCI2.Prasugrel (PCR 4099) reduces the aggregation (clumping) of platelets by irreversibly binding to P2Y12receptors. In rat platelets, prasugr

6、el hydrochloride AM inhibited in vitro platelet aggregation induced by ADP(10 m) with an IC50 value of 1.8 m 2.REFERENCES1. Sugidachi A, et al. The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of itsactive metabolite with similar anti

7、platelet activity to that of clopidogrels active metabolite. J Thromb Haemost. 2007 Jul;5(7):1545-51. Epub2007 Apr 19.2. Baker WL, et al. Role of prasugrel, a novel P2Y(12) receptor antagonist, in the management of acute coronary syndromes. Am JCardiovasc Drugs. 2009;9(4):213-29.McePdfHeightCaution: Product has not been fully validated for medical applications.For research us