BPA(雙酚A介紹)英文版課件

1、Since You Asked - Bisphenol A (BPA)Questions and Answers about Bisphenol A by GC0902Since You Asked - Bisphenol A BPAWhat is BPAWhere is BPA foundHow does BPA get into the bodyDetermination of BPATo prevent exposure to BPAsince you asked BPABPAWhat is BPAWhere is BPA fouNEWShormone-disruptingNEWShor

2、mone-disruptingU.S.A2009/3EU2011/3/1Canada2008/5CN2011/6/1NEWSU.S.AEUCanadaCNNEWSWhat is bisphenol A?Bisphenol A (BPA) is a chemical produced in large quantities for use primarily in the production of polycarbonate plastics and epoxy resins.What is bisphenol A?Bispheno1891This compound is synthesize

3、d by thecondensationofacetone(hence the suffix A in the name)with twoequivalentsofphenol. The reaction iscatalyzedby a strong acid.Industrially, a large excess of phenol is used to ensure full condensation; the product mixture of thecumene process(acetone and phenol) may also be used as starting mat

4、erial :phenol. BisphenolAphenol. BisphenolA1891phenol. BisphenolAphenoWhere is BPA found?food and drink packaging, e.g., water and infant bottles, compact discs, impact-resistant safety equipment, and medical devices. metal products such as food cans, bottle tops, and water supply pipes. dental seal

5、ants and compositesWhere is BPA found?food and dHow does BPA get into the body?The primary source of exposure to BPA for most people is through the diet. While air, dust, and water are other possible sources of exposure, BPA in food and beverages accounts for the majority of daily human exposure.Bis

6、phenol A can leach into food from the protective internal epoxy resin coatings of canned foods and from consumer products such as polycarbonate tableware, food storage containers, water bottles, and baby bottles.The degree to which BPA leaches from polycarbonate bottles into liquid may depend more o

7、n the temperature of the liquid or bottle, than the age of the container.How does BPA get into the bodDetermination of BPA in food simulantsReagentsApparatusProcedureExpression of resultsFromCEN/TS 13130-13:2005Determination of BPA in food ReagentsBPAn-HexaneMethanolDeionized water Extraction solven

8、t, methanol/water=1:1Mobile phase for HPLC methanol/water=70:30Stock solution of BPA in methanol at a defined concentration of approximately 0.38mg/mlReagentsBPAApparatusHigh performance liquid chromatographyHPLC columnMechanical shaker (vortex) Micro syringesTest tubesApparatusHigh performance liqP

9、rocedureHPLC analysis Calibration Execution of determination HPLC interferences ProcedureHPLC analysisExpression of results1. Graphical determinationExpression of results1. GraphBPA(雙酚A介紹)英文版課件Expression of results2. Calculation from the regression parameters. If the regression line equation is: y=(

10、ax)+bthe peak area of BPAthe slope of the regression line in milligrams per kilogramthe concentration of BPA in the food simulant in milligrams per kilogramthe intercept of the regression lineExpression of results2. Calcuthe concentration of BPA in the food stimulant in given by: C=(y-b)/athe concen

11、tration of BPA in thIf I am concerned, what can I do to prevent exposure to BPA?Plastic containers have recycle codes on the bottom. Reduce your use of canned foods.When possible, opt for glass, porcelain or stainless steel containers, particularly for hot food or liquids.Use baby bottles that are BPA free. Dont microwave polycarbonate plastic food containers