1-5-Isoquinolinediol-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE1,5-IsoquinolinediolCat. No.: HY-W015422CAS No.: 5154-02-9分式: CHNO分量: 161.16作靶點(diǎn): PARP作通路: Cell Cycle/DNA Damage; Epigenetics儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 37.04 mg/mL (229.

2、83 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 6.2050 mL 31.0251 mL 62.0501 mL5 mM 1.2410 mL 6.2050 mL 12.4100 mL10 mM 0.6205 mL 3.1025 mL 6.2050 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 1,5-Isoquinolinediol種 有效的 PARP 抑制劑，IC50 值為 0.18-0.37 M。1,5

3、-Isoquinolinediol 減輕糖尿病誘導(dǎo)的視膜 NADPH 氧化酶誘導(dǎo)的氧化應(yīng)激。IC50 & Target PARP0.18-0.37 M (IC50)體外研究1,5-isoquinolinediol leads to an increase up to 8-fold in the absolute frequency of gene targeting in the1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEcorrection of the mutation at the stable integrated HSV tk g

4、ene 1.1,5-Isoquinolinediol is a potent PARP antagonist and decreases cleaved PARP in diabetic retina.1,5-Isoquinolinediol (500 M H2O2; 24 hours) attenuates H2O2-induced upregulation of cleaved PARP-1expression in retinal Muller cells. 1,5-Isoquinolinediol attenuates diabetes-induced upregulation of

5、retinalnitrated protein expression. 1,5-Isoquinolinediol attenuates diabetes-induced activation of NADPH oxidase inthe retina 2.REFERENCES1. Crockett SL, et al. Role of dopamine and selective dopamine receptor agonists on mouse ductus arteriosus tone and responsiveness.Pediatr Res. 2019 Dec 9.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021