Bepridil-hydrochloride-hydrate-racemic-Bepridil-hydrochloride-hydrate-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBepridil hydrochloride hydrateCat. No.: HY-16952ACAS No.: 74764-40-2Synonyms: ()-Bepridil hydrochloride hydrate; Org 5730 hydrochloridehydrate分式: CHClNO分量: 421.02作靶點: Calcium Channel作通路: Membrane Transporter/Ion Channel; Neurona

2、l Signaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 250 mg/mL (593.80 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.3752 mL 11.8759 mL 23.7518 mL5 mM 0.4750 mL 2.3752 mL 4.7504 mL10 mM 0.2375 mL 1.1876 mL

3、 2.3752 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Bepridil hydrochloride hydrate ()-Bepridil hydrochloride hydrate)選擇性的，長效的鈣離通道 (Ca+channel) 拮抗劑，鈉離、鉀離通道 (Na+, K+ channel) 抑制劑，具有抗絞痛和抗 I 型律失常作。Bepridil hydrochloride hydrate 也臟 Na+/Ca2+ 交換 (NCX1) 抑制劑。Bepridil hydrochloride hy

4、drate 可于管疾病的研究 1 2 3 4 5。1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEIC50 & Target Ca2+體外研究 Bepridil hydrochloride hydrate blockades of Ca2+-dependent action potentials in vascular smooth muscle ofdog coronary artery 2.Bepridil hydrochloride hydrate blocks Ca currents and Na currents with IC50s

5、 of 0.5 M and 30 M,respectively in cultured ventricular cells 4.Bepridil hydrochloride hydrate decreases IKs under blockade of IKr with E4031 (5 M), in a concentration-dependent manner 5.體內(nèi)研究 Bepridil hydrochloride hydrate exhibits a half-life of averages 3315 hours after single-dose administration6

6、.REFERENCES1. A Gill, et al. Pharmacology of Bepridil. Am J Cardiol. 1992 Apr 9;69(11):11D-16D.2. D R Harder, et al. Bepridil Blockade of Ca2+-dependent Action Potentials in Vascular Smooth Muscle of Dog Coronary Artery. JCardiovasc Pharmacol. Jul-Aug 1981;3(4):906-14.3. Yasuhide Watanabe. Cardiac N

7、a +/Ca 2+ Exchange Stimulators Among Cardioprotective Drugs. J Physiol Sci. 2019 Nov;69(6):837-849.4. A Yatani, et al. Bepridil Block of Cardiac Calcium and Sodium Channels. J Pharmacol Exp Ther. 1986 Apr;237(1):9-17.5. J C Wang, et al. Bepridil Differentially Inhibits Two Delayed Rectifier K(+) Currents, I(Kr) and I(Ks), in Guinea-Pig Ventricular Myocytes.Br J Pharmacol. 1999 Dec;128(8):1733-8.6. L Z Benet, et al. Pharmacokinetics and Metabolism of Bepridil. Am J Cardiol. 1985 Mar 15;55(7):8C-13C.McePdfHeightCaution: Product has not been fully validated for medical applications.For