TTP-8307-DataSheet-生命科學(xué)試劑-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemETTP-8307Cat.No.:HY-124806CASNo.:950225-08-8分?式:C??H??FN?O分?量:436.48作?靶點(diǎn):Enterovirus;DNA/RNASynthesis;HCV作?通路:Anti-infection;CellCycle/DNADamage儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCOA.溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:100mg/mL(229.11mM;Needultrasonic)H2O:<0.1mg/mL(insoluble)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.2911mL11.4553mL22.9106mL5mM0.4582mL2.2911mL4.5821mL10mM0.2291mL1.1455mL2.2911mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存?式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案，配制前請(qǐng)先配制澄的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分?指該溶劑在您配制終溶液中的體積占?)：1.請(qǐng)依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:2.5mg/mL(5.73mM);Suspendedsolution;Needultrasonic2.請(qǐng)依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:2.5mg/mL(5.73mM);Suspendedsolution;Needultrasonic3.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(5.73mM);Clearsolution1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性TTP-8307?種?和腸道病毒(rhino-/enteroviruses)復(fù)制的有效抑制劑。TTP-8307通過(guò)?擾病毒RNA的合成抑制coxsackievirusB3病毒(CVB3;EC50=1.2μM)和poliovirus病毒。TTP-8307通過(guò)氧化甾醇結(jié)合蛋?(OSBP)發(fā)揮抗病毒活性。體外研究TTP-8307targetsthenonstructuralprotein3A,inhibitsthereplicationofcoxsackievirusB3(CVB3Nancy)withEC50of1.2μM.TTP-8307inhibitsthereplicationofcoxsackievirusB3andthethreepoliovirusSabinstrains,aswellascoxsackievirusesA16andA21(EC50of0.85and5.34μM).TTP-8307inhibitshumanrhinoviruses(HRVs)2,29,39,45,63,and85.Mutationsinthenonstructuralprotein3AconferresistancetothenovelenterovirusreplicationinhibitorTTP-8307[1].TTP-8307inhibitsOSBP-dependentvirusesencephalomyocarditisvirus(EMCV)andHCV[2].REFERENCES[1].DePalmaAM,etal.Mutationsinthenonstructuralprotein3AconferresistancetothenovelenterovirusreplicationinhibitorTTP-8307.AntimicrobAgentsChemother.2009May;53(5):1850-7.[2].AlbulescuL,etal.Uncoveringoxysterol-bindingprotein(OSBP)asatargetoftheanti-enteroviralcompoundTTP-8307.AntiviralRes.2017Apr;140:37-44.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearch