鼻竇鱗狀細(xì)胞癌課件

鼻竇鱗狀細(xì)胞癌大頭醫(yī)生編輯整理鼻竇鱗狀細(xì)胞癌1英文名稱squamouscellcarcinomaoftheparanasalsinus英文名稱2別名鼻竇扁平細(xì)胞癌;鼻竇鱗狀上皮細(xì)胞癌別名3類別眼科/眼眶疾病/眼眶繼發(fā)性腫瘤及轉(zhuǎn)移性腫瘤/鼻竇惡性腫瘤類別4ICD號C79.8ICD號5概述眼眶幾乎被鼻竇包圍,其下方有上頜竇,內(nèi)側(cè)有篩竇,上方有額竇,后面是蝶竇。除蝶竇外,上頜竇的頂即眶底,篩竇的篩骨紙板即眶內(nèi)壁,額竇底部外3/4區(qū)為眼眶頂?shù)囊徊糠?均為一層較薄的骨板將眼眶與鼻竇隔開。鼻竇的腫瘤直接侵蝕這些薄骨板到達(dá)眼眶,同時腫瘤也可經(jīng)骨板上的神經(jīng),血管通道進(jìn)入眼眶。蝶竇外側(cè)壁與海綿竇及頸動脈密切相關(guān),第Ⅲ、ⅣⅤ、Ⅵ腦神經(jīng)在此壁和硬腦膜之間行經(jīng)。上壁前部與左右視神經(jīng)及視束交叉相近,故蝶竇腫瘤常并發(fā)眼外肌麻痹,三叉神經(jīng)痛和視功能改變。概述6概述鼻竇鱗狀細(xì)胞癌(squamouscellcarcinomaoftheparanasalnus發(fā)生在所有的鼻竇,但以上頜竇最為常見。而在其他竇腔中鱗狀細(xì)胞癮也為首發(fā)病概述7流行病學(xué)上頜竇的惡性腫瘤的鱗狀細(xì)胞癌常見,可以占到該竇腫瘤的60%~93%。約65%的鼻竇惡性腫瘤均會侵襲眼眶。流行病學(xué)8病因鼻竇黏膜直接與外界空氣接觸,常受到不良因素的影響,是惡性腫瘤的好發(fā)部位,與多種致瘤因素有關(guān),如病毒感染、遺傳、放射性損傷及環(huán)境污染等。病因9發(fā)病機制各種致癌因素作用于細(xì)胞的遺傳物質(zhì),引起遺傳密碼的改變,使某些關(guān)鍵的細(xì)胞調(diào)控基因突變或過高表達(dá),這些遺傳物質(zhì)可按照遺傳法則不斷傳給子代細(xì)胞。有些細(xì)胞接近胚胎的幼稚細(xì)胞,失去了發(fā)育成熟的能力,在局部異常增生而形成新生物。發(fā)病機制10鼻竇鱗狀細(xì)胞癌課件11鼻竇鱗狀細(xì)胞癌課件12鼻竇鱗狀細(xì)胞癌課件13鼻竇鱗狀細(xì)胞癌課件14鼻竇鱗狀細(xì)胞癌課件15鼻竇鱗狀細(xì)胞癌課件16鼻竇鱗狀細(xì)胞癌課件17鼻竇鱗狀細(xì)胞癌課件18鼻竇鱗狀細(xì)胞癌課件19鼻竇鱗狀細(xì)胞癌課件20鼻竇鱗狀細(xì)胞癌課件21鼻竇鱗狀細(xì)胞癌課件22鼻竇鱗狀細(xì)胞癌課件23鼻竇鱗狀細(xì)胞癌課件24鼻竇鱗狀細(xì)胞癌課件25鼻竇鱗狀細(xì)胞癌課件26鼻竇鱗狀細(xì)胞癌課件27鼻竇鱗狀細(xì)胞癌課件28鼻竇鱗狀細(xì)胞癌課件29鼻竇鱗狀細(xì)胞癌課件30鼻竇鱗狀細(xì)胞癌課件31鼻竇鱗狀細(xì)胞癌課件32鼻竇鱗狀細(xì)胞癌課件33鼻竇鱗狀細(xì)胞癌課件34鼻竇鱗狀細(xì)胞癌課件35鼻竇鱗狀細(xì)胞癌大頭醫(yī)生編輯整理鼻竇鱗狀細(xì)胞癌36英文名稱squamouscellcarcinomaoftheparanasalsinus英文名稱37別名鼻竇扁平細(xì)胞癌;鼻竇鱗狀上皮細(xì)胞癌別名38類別眼科/眼眶疾病/眼眶繼發(fā)性腫瘤及轉(zhuǎn)移性腫瘤/鼻竇惡性腫瘤類別39ICD號C79.8ICD號40概述眼眶幾乎被鼻竇包圍,其下方有上頜竇,內(nèi)側(cè)有篩竇,上方有額竇,后面是蝶竇。除蝶竇外,上頜竇的頂即眶底,篩竇的篩骨紙板即眶內(nèi)壁,額竇底部外3/4區(qū)為眼眶頂?shù)囊徊糠?均為一層較薄的骨板將眼眶與鼻竇隔開。鼻竇的腫瘤直接侵蝕這些薄骨板到達(dá)眼眶,同時腫瘤也可經(jīng)骨板上的神經(jīng),血管通道進(jìn)入眼眶。蝶竇外側(cè)壁與海綿竇及頸動脈密切相關(guān),第Ⅲ、ⅣⅤ、Ⅵ腦神經(jīng)在此壁和硬腦膜之間行經(jīng)。上壁前部與左右視神經(jīng)及視束交叉相近,故蝶竇腫瘤常并發(fā)眼外肌麻痹,三叉神經(jīng)痛和視功能改變。概述41概述鼻竇鱗狀細(xì)胞癌(squamouscellcarcinomaoftheparanasalnus發(fā)生在所有的鼻竇,但以上頜竇最為常見。而在其他竇腔中鱗狀細(xì)胞癮也為首發(fā)病概述42流行病學(xué)上頜竇的惡性腫瘤的鱗狀細(xì)胞癌常見,可以占到該竇腫瘤的60%~93%。約65%的鼻竇惡性腫瘤均會侵襲眼眶。流行病學(xué)43病因鼻竇黏膜直接與外界空氣接觸,常受到不良因素的影響,是惡性腫瘤的好發(fā)部位,與多種致瘤因素有關(guān),如病毒感染、遺傳、放射性損傷及環(huán)境污染等。病因44發(fā)病機制各種致癌因素作用于細(xì)胞的遺傳物質(zhì),引起遺傳密碼的改變,使某些關(guān)鍵的細(xì)胞調(diào)控基因突變或過高表達(dá),這些遺傳物質(zhì)可按照遺傳法則不斷傳給子代細(xì)胞。有些細(xì)胞接近胚胎的幼稚細(xì)胞,失去了發(fā)育成熟的能力,在局部異常增生而形成新生物。發(fā)病機制45鼻竇鱗狀細(xì)胞癌課件46鼻竇鱗狀細(xì)胞癌課件47鼻竇鱗狀細(xì)胞癌課件48鼻竇鱗狀細(xì)胞癌課件49鼻竇鱗狀細(xì)胞癌課件50鼻竇鱗狀細(xì)胞癌課件51鼻竇鱗狀細(xì)胞癌課件52鼻竇鱗狀細(xì)胞癌課件53鼻竇鱗狀細(xì)胞癌課件54鼻竇鱗狀細(xì)胞癌課件55鼻竇鱗狀細(xì)胞癌課件56鼻竇鱗狀細(xì)胞癌課件57鼻竇鱗狀細(xì)胞癌課件58鼻竇鱗狀細(xì)胞癌課件59鼻竇鱗狀細(xì)胞癌課件60鼻竇鱗狀細(xì)胞癌課件61鼻竇鱗狀細(xì)胞癌