Thiamine-disulfide-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEThiaminedisulfideCat.No.:HY-B2224CASNo.:67-16-3分?式:C??H??N?O?S?分?量:562.71作?靶點(diǎn):HIV;EndogenousMetabolite作?通路:Anti-infection;MetabolicEnzyme/Protease儲(chǔ)存?式:4°C,protectfromlight,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light,storedundernitrogen)溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:250mg/mL(444.28mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM1.7771mL8.8856mL17.7711mL5mM0.3554mL1.7771mL3.5542mL10mM0.1777mL0.8886mL1.7771mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month(protectfromlight,storedundernitrogen)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.08mg/mL(3.70mM);Clearsolution2.請(qǐng)依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.08mg/mL(3.70mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE3.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(3.70mM);ClearsolutionBIOLOGICALACTIVITY?物活性Thiaminedisulfide?種維?素B1衍?物，Thiamine的氧化?聚體。Thiaminedisulfide?種有效的HIV-1抑制劑，可顯抑制HIV-1反式激活因?(Tat)的活性。體外研究ThiaminedisulfidemarkedlyinhibitsproductionofprogenyHIV-1inacuteandchronicHIV-1-infectedCEMatnontoxicconcentrationsof500-1000μM.Thiaminedisulfide(500μM)blocks99.7%ofHIV-1productionafter96hourscultureinacuteHIV-1(LAV-1)infection,whereasitinhibits90-98%ofHIV-1productioninchronic-infectedcells(CEM/LAV-1,H9/MN,andMolt-4/IIIB)[1].REFERENCES[1].SShoji,etal.Thiaminedisulfideasapotentinhibitorofhumanimmunodeficiencyvirus(type-1)production.BiochemBiophysResCommun.1994Nov30;205(1):967-75.[2].YKomata,etal.Invitropercutaneousabsorptionofthiaminedisulfidefromamixtureofpropyleneglycolandfattyacid.JPharmSci.1992Aug;81(8):744-6.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseon