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5/5CURRICULUMVITAE************,M。D.,Ph。D。Address:DepartmentofNeurology,**************lHospital********,Beijing******,P.R.ChinaPhone:?**************E-mail:**************Researchobjectives:Vascularpathologyinstroke,GeneticresearchinCMT,FunctionalMRinstrokeIntra—arterial/venousthrombolysisinacutecerebralinfarctionCareerAimsShort-term:Toprocureapost-doctoralvacancyabroadfor1or2yearstobroadenmyview,toenhancemyskillsandtoacquiretheabilitytomeettherequirementofhigherstandardofwork.Myinterestsare:PathologyinADandVaDGeneticresearchinCMTandCADASILFunctionalMRinStrokeLong—term:Tocooperatewithmoree(cuò)xpertsandbecamemoreandmoreexpertinNeurologicalresearch.EDUCATION2003-2006:Ph。D。inNeurology,The********University,Chongqing,P.R.ChinaThesis:************************Advisor:Prof.**************Inthisstudy,I**************2000-2003:M.S.studiesinNeurology,The**************University,Chongqing,P.R.ChinaThesis:**************Advisor:Prof.**************Thisprojectistoanalysis**************1995-2000:M.D.inclinicalmedicine,The**************University,Chongqing,P.R.ChinaAPPOINTMENTS01/2009-Present:Chief—Resident,DepartmentofNeurology,**************Hospital10/2007—Present:Instructor,Physician—in—charge,DepartmentofNeurology,**************Hospital10/2000-10/2007:Physician-resident,DepartmentofNeurology,**************HospitalHONORSANDAWARDS ?? 2007:ExcellentPhysician-resident,**************Hospital2010:ExcellentChief-Resident,BeijingMilitaryGeneralHospitalRESEARCHExperiencePrincipalinaprojectsupportedbytheNationalScienceFoundat(yī)ionofChina(Grant#30800357).Thisproject,whichwillbefinishedinJuly,2011,istostudytherelationshipbetweenphenotypeswitchofVSMCandNotch3。MainparticipatorinaprojectsupportedbyNationalScienceFoundationofChina(Grant#30470609),Inthisproject,IhavefoundwhentheFLNmRNAinVSMCwassuppressedbyRNAi,theproliferationofVSMCwasdescendedandtheswitchfromContractilphenotypetoSyntheticphenotypewasblocked。ThisresultwillbepublishedinCellBiochemistryandBiophysics(IF:4.37)inafewmonths。Ihavefoundahugefamily(〉250persons,familytreeisinappendix)ofCMT,butthemutationcann'tbeidentifiedwithcommonmethod。Nowweusewhole—exonsequencingtoidentifiesthemutationsandtheresultwillcameoutinafewwee(cuò)ks.Ialsoamfamiliarwiththeprotocolofclinictrialandattendinsomeinternationalclinictrials。Theseinclude:PROFESS(PreventionRegimenforEffectivelyAvoidingSecondStrokes),INTERACT(IntensiveBloodPressureReductioninAcuteCerebralHemorrhageTrial)ESPRIT(Europeanstrokepreventioninreversibleischemiatrial),CASTA(CerebrolysininpatientswithAcuteischemicStrokeinAsia),andetal。NowIamthememberoftheEthiccommitteeinmyhospital.SELECTEDPublicationsProfessionalAFFILIATIONslaborat(yī)orySkillsIntensiveexperienceinNeuropat(yī)hologyandneuroimaging.In2001,StudythemethodofNeuropat(yī)hologyundertheProf.Magerittafor6months.ShewasaneurologistinDept。Neuropathology,UPSALAuniversity,Sweden。Intheperiod,Ilearnedthemethodofpathologyandneuropathology,includeofImmunohistochemistry,Immunofluorescence,insituhybridizationandsoon。In2003,takepartinaneuropat(yī)hologytrainingcourseholdbytheneuropathologicalbranchofCMAforonemonth.In2005and2009,takepartintheadvancedneuropathologytrainingcoursesforhalfamontheachtime。Afterthesecourses,Ilearnedthepat(yī)hologicaldiagnosisofmanyneurologicaldiseases.In2009,takepartintheneuroimagingtrainingcourseholdbyneuroimagingbranchofCMAfor3months。ThiscoursewastostudytheMRIdiagnosisofneurologicaldisease,whichincludeofcerebralvasculardisease,cerebraltumorandDegeneration.IcanreadcerebralorspinalCTscansorMRscansandmakethediagnosisindependently.Iamfamiliarwiththeimagingchangesofcerebralinfarction,cerebralhemorrhage,MS,cerebralinfectiousdiseaseandcerebraltumors。Inmyclinicalpractice,Ihavediagnosedmanyintractablecasesbymyself,whichincludeofreversibleposteriorleukoencephalopathysyndrome(RPLES),Wernicke′sencephalopathy,CerebralVenousThrombosis,progressivesupranuclearpalsy(PSP),Creutzfeldt–Jakobdisease(CJD),cavernousmalformation,centralpontinemyelinolysis(CPM),extra-pontinemyelinolysis(EPM),gliomatosiscerebri,primarycentralnervoussystemlymphoma(PCNSL),Tolosa—Huntsyndrome,multiplesystematrophy(MSA),mitochondrialmyopathyandsoon.From2006tonow,IstudytheMRchangeandgeneticmutationofCADASIL.Ihadgotmorethan10familiesofCADASIL。Morethan50personsinthesefamiliesweredetectedthemutationofgeneorsomechangeinMRimaging。Thearticlewillbefinishedinnomorethanoneyear.Familiarwithcommonmolecularbiologytechnology,includingPCRandRT-PaCR,SSCP,RFLP,genotyping,primerandprobedesign,plasmidpreparat(yī)ion,Lipos

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